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Biomimetic one-pot synthesis of gold nanoclustersanoparticles for targeted tumor cellular dual-modality imaging

机译：金纳米团簇/纳米颗粒的仿生一锅合成用于靶向肿瘤细胞双模态成像。

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摘要

Biomimetic synthesis has become a promising green pathway to prepare nanomaterials. In this study, bovine serum albumin (BSA)-conjugated gold nanoclustersanoparticles were successfully synthesized in water at room temperature by a protein-directed, solution-phase, green synthetic method. The synthesized BSA-Au nanocomplexes have fluorescence emission (588 nm) of gold nanoclusters and surface plasmon resonance of gold nanoparticles. The BSA-Au nanocomplexes display non-cytotoxicity and excellent biocompatibility on MGC803 gastric cancer cells. After conjugation of folic acid molecules, the obtained BSA-Au nanocomplexes showed highly selective targeting for MGC803 cells and dual-modality dark-field and fluorescence imaging.

机译：仿生合成已成为制备纳米材料的有前途的绿色途径。在这项研究中，牛血清白蛋白（BSA）共轭的金纳米团簇/纳米颗粒在室温下通过蛋白质定向，溶液相，绿色合成方法成功合成。合成的BSA-Au纳米复合物具有金纳米团簇的荧光发射（588 nm）和金纳米颗粒的表面等离子体共振。 BSA-Au纳米复合物对MGC803胃癌细胞显示出非细胞毒性和出色的生物相容性。叶酸分子结合后，获得的BSA-Au纳米复合物对MGC803细胞具有高度选择性的靶向性，并具有双峰暗场和荧光成像。

著录项

期刊名称 Nanoscale Research Letters
作者
Jing Lin; Zhijun Zhou; Zhiming Li; Chunlei Zhang; Xiansong Wang; Kan Wang; Guo Gao; Peng Huang; Daxiang Cui;
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作者单位

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年(卷),期 2013(8),1
年度 2013
页码 170
总页数 7
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
Bovine serum albumin Gold nanocluster Gold nanoparticle Folic acid Cellular imaging;

机译：牛血清白蛋白;金纳米簇;金纳米颗粒;叶酸;细胞成像;

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1. Facile synthesis of functional gadolinium-doped CdTe quantum dots for tumor-targeted fluorescence and magnetic resonance dual-modality imaging [J] . Fei Zhang, Ting-Ting Sun, Yan Zhang Journal of Materials Chemistry, B. materials for biology and medicine . 2014,第41期

机译：易于合成功能性lin掺杂的CdTe量子点，用于肿瘤靶向的荧光和磁共振双峰成像
2. One-pot synthesis of near-infrared fluorescent gold clusters for cellular fluorescence lifetime imaging [J] . Shang L., Azadfar N., Stockmar F., Small . 2011,第18期

机译：一锅合成近红外荧光金簇用于细胞荧光寿命成像
3. A human endogenous protein exerts multi-role biomimetic chemistry in synthesis of paramagnetic gold nanostructures for tumor bimodal imaging [J] . Yang Weitao, Wu Xiaoli, Dou Yan, Biomaterials . 2018,第期

机译：人内源性蛋白在肿瘤双峰成像的合成中施加多角色仿生化学
4. Dual-modality in vivo imaging for MRI detection of tumors and NIRF-guided surgery using multi-component nanoparticles [C] . Jaehong Key, Kwangmeyung Kim, Deepika Dhawan, Conference on nanoscale imaging, sensing, and actuation for biomedical applications VIII . 2011

机译：使用多组分纳米粒子的双模式体内成像，用于MRI肿瘤检测和NIRF指导的手术
5. Part I. Design, synthesis and biological evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents. Part II. Development of novel taxoid-based drug conjugates and theranostic imaging agents towards tumor-targeted chemotherapy. [D] . Park, Bora. 2014

机译：第一部分：针对FtsZ作为抗结核药的新型2,5,6-三取代苯并咪唑的设计，合成和生物学评估。第二部分新型基于紫杉醇的药物结合物和治疗诊断剂在肿瘤靶向化疗中的应用。
6. One-step Rapid and Green Synthesis of Multifunctional Gold Nanoparticles for Tumor-Targeted Imaging and Therapy [O] . Hua Qin Yin, Guang Shao, Feng Gan, 2020

机译：一步法快速绿色合成多功能金纳米颗粒用于肿瘤靶向成像和治疗
7. Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging [O] . 2013

机译：金纳米团簇/纳米颗粒的仿生一锅合成用于靶向肿瘤细胞双模态成像。

Biomimetic one-pot synthesis of gold nanoclustersanoparticles for targeted tumor cellular dual-modality imaging

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