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首页> 美国卫生研究院文献>Drugs in RD >Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery
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Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

机译：不同剂量的帕洛诺司琼预防斜视手术患儿术后恶心和呕吐的预防

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>Objective: The aim of this study was to evaluate the efficacy of different doses of palonosetron for the prevention of PONV in children undergoing strabismus surgery.>Patients and Method: A total of 150 children who were classified with an American Society of Anesthesiologists physical status of I, were aged between 2 and 12 years, and were undergoing strabismus surgery under general anesthesia were enrolled in the study. A random numbers table was used to assign each child to receive palonosetron 0.5, 1.0, or 1.5 μg/kg (n = 50 in each group).All episodes of PONVat the intervals of 0–2, 2–6, 6–24, and 24–48 hours were evaluated using a numeric scoring system for PONV. A p-value of <0.05 was considered statistically significant.>Results: The percentage of children with PONV during 0–48 hours after anesthesia was 24% with palonosetron 0.5 or 1.0 μg/kg, and 20% with palonosetron 1.5 μg/kg. There was no statistically significant difference between the study groups with respect to the number of children with PONV scores of 1, 2, or 3 during 0–48 hours after anesthesia. There was no statistically significant difference between the study groups with respect to the number of children with postoperative vomiting during all time periods after anesthesia. The percentage of children aged >6 years with postoperative nausea during 0–48 hours after anesthesia was 8.6%, 18.2%, and 15.4% with palonosetron 0.5, 1.0, or 1.5 μg/kg, respectively, but there was no statistically significant difference between the study groups.>Conclusion: Palonosetron doses of 0.5, 1.0, and 1.5 μg/kg are recommended for further evaluation, as they appear to be the effective doses for the prevention of PONV following strabismus surgery in children.
机译：>目的：该研究的目的是评估不同剂量的帕洛诺司琼对斜视手术患儿预防PONV的疗效。>患者和方法：共计150根据美国麻醉医师学会I物理状态分类的儿童，年龄在2至12岁之间，并在全身麻醉下接受斜视手术的儿童入选了该研究。使用随机数字表分配每个儿童接受帕洛诺司琼0.5、1.0或1.5μg/ kg（每组n = 50）。所有PONV发作的间隔为0–2、2–6、6–24，使用PONV的数字评分系统对24-48小时进行了评估。 p值<0.05被认为具有统计学意义。>结果：麻醉后0-48小时内，PONLON儿童的比例为：帕洛诺司琼0.5或1.0μg/ kg时为24％，而帕洛诺司琼为0.5％/ 1.0μg/ kg。帕洛诺司琼1.5μg/ kg。在麻醉后0–48小时内，PONV评分为1、2或3的儿童数量方面，各研究组之间无统计学差异。在麻醉后的所有时间段内，研究组之间在术后呕吐的儿童数量上没有统计学上的显着差异。帕洛诺司琼分别为0.5、1.0或1.5μg/ kg时，麻醉后0-48小时内> 6岁的患儿出现恶心的比例分别为8.6％，18.2％和15.4％，但两者之间无统计学差异。 >结论：建议使用帕洛诺司琼剂量0.5、1.0和1.5μg/ kg进行进一步评估，因为它们似乎是预防儿童斜视术后PONV的有效剂量。

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