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THE EFFECT OF THE HYDROGEN ION CONCENTRATION ON THE RATE OF HYDROLYSIS OF GLYCYL GLYCINE GLYCYL LEUCINE GLYCYL ALANINE GLYCYL ASPARAGINE GLYCYL ASPARTIC ACID AND BIURET BASE BY EREPSIN

机译：氢离子浓度对蛇皮蛋白对甘氨酸甘氨酸甘氨酸丙氨酸甘氨酸天冬酰胺甘氨酸天冬氨酸和缩二脲碱的水解速率的影响

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1. The rate of hydrolysis at different pH values of glycyl glycine, glycyl leucine, glycyl alanine, glycyl asparagine, glycyl aspartic acid and biuret base has been determined. 2. The pH-activity curves obtained in this way differ for the different substrates. 3. The curves can be satisfactorily predicted by the assumption that erepsin is a weak acid or base with a dissociation constant of 10^–7.6 and that the reaction takes place between a particular ionic species of the enzyme and of the substrate. There are several possible arrangements which will predict the experimental results. 4. The rate of inactivation of erepsin at various pH values has been determined and found to agree with the assumption used above, that the enzyme is a weak acid or base with a dissociation constant of about 10^–7.6. 5. It is pointed out that if the mechanism assumed is correct, the determination of a significant value for the relative rate of hydrolysis of various peptides is a very uncertain procedure.

机译：1.已测定了在不同pH值下的甘氨酰甘氨酸，甘氨酰亮氨酸，甘氨酰丙氨酸，甘氨酰天冬酰胺，甘氨酰天冬氨酸和缩二脲碱的水解速率。 2.对于不同的底物，以此方式获得的pH活性曲线不同。 3.可以通过以下假设来令人满意地预测曲线，即：蛇毒素是一种弱酸或弱碱，其解离常数为10 ^{–7.6 ，并且该反应发生在特定的离子型酶和基板。有几种可能的安排可以预测实验结果。 4.已经确定了在各种pH值下，蛇毒素的失活速率，并与上述假设一致，即该酶是一种弱酸或弱碱，其解离常数约为10 ^{–7.6 。 5.指出，如果假设的机制是正确的，那么确定各种肽的相对水解速率的显着值是非常不确定的程序。}}

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期刊名称 The Journal of General Physiology
作者
John H. Northrop; Henry S. Simms;
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年(卷),期 1928(12),2
年度 1928
页码 313–328
总页数 16
原文格式 PDF
正文语种
中图分类人体生理学;
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专利

1. THE EFFECT OF THE HYDROGEN ION CONCENTRATION ON THE RATE OF HYDROLYSIS OF GLYCYL GLYCINE, GLYCYL LEUCINE, GLYCYL ALANINE, GLYCYL ASPARAGINE, GLYCYL ASPARTIC ACID, AND BIURET BASE BY EREPSIN [J] . John H. Northrop, Henry S. Simms The Journal of general physiology . 1928,第2期

机译：氢离子浓度对甘油三酸酯，甘氨酸，甘油丙氨酸，甘氨酸天冬酰胺，甘氨酸天冬氨酸和缩二脲碱的水解速率的影响
2. Electron density and electrostatic properties of two peptide molecules: tyrosyl-glycyl-glycine monohydrate and glycyl-aspartic acid dihydrate [J] . Pichon-Pesme V., Souhassou M., Lecomte C., Acta Crystallographica, Section B. Structural Science . 2000,第4期

机译：两种肽分子的电子密度和静电性质：酪氨酰-甘氨酰-甘氨酸一水合物和甘氨酰-天冬氨酸二水合物
3. Structural and Spectroscopic Elucidation of Tetrapetide Glycyl-L-Prolyl-Glycyl-Glycine and Its Hydrogensquarate [J] . Tsonko M. Kolev Protein and Peptide Letters . 2008,第7期

机译：四肽甘氨酰-L-脯氨酰-甘氨酰-甘氨酸及其氢方酸的结构和光谱解析
4. Synthesis and biological activity of N-(tert-butyloxycarbonyl)-(adamant-2-yl)-DL-glycyl-peptidoglycan monomer [C] . Vesna Sporec, Durdica Ljevakovic, Beata Halassy Spoljar, European Peptide Symposium . 2002

机译：N-（叔丁基氧基羰基） - （铝烷-2-基）-D1-甘氨酸 - 肽聚糖单体的合成及生物活性
5. Structure and Properties of the Hydrogel-Forming Tripeptide Glycyl-Histidyl-Glycine With Varying Sample Composition [D] . Hesser, Morgan Leigh. 2020

机译：具有不同样品组合物的水凝胶形成三肽糖基 - 组氨基 - 甘氨酸的结构和性质
6. Glycyl-L-glutamine a precursor and glycyl-L-glutamic acid a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo. [O] . G B Koelle, U J Sanville, S J Wall 1985

机译：甘氨酰-L-谷氨酰胺（一种前体）和甘氨酰-L-谷氨酸（一种用于在猫的神经节前去神经支配的神经营养因子中维持乙酰胆碱酯酶和丁酰胆碱酯酶的神经营养因子）。
7. THE EFFECT OF THE HYDROGEN ION CONCENTRATION ON THE RATE OF HYDROLYSIS OF GLYCYL GLYCINE, GLYCYL LEUCINE, GLYCYL ALANINE, GLYCYL ASPARAGINE, GLYCYL ASPARTIC ACID, AND BIURET BASE BY EREPSIN [O] . Northrop, John H., Simms, Henry S. 1928

机译：氢离子浓度对蛇皮蛋白对甘氨酸，甘氨酸，甘氨酸丙氨酸，甘氨酸天冬酰胺，甘氨酸天冬氨酸和缩二脲碱的水解速率的影响

THE EFFECT OF THE HYDROGEN ION CONCENTRATION ON THE RATE OF HYDROLYSIS OF GLYCYL GLYCINE GLYCYL LEUCINE GLYCYL ALANINE GLYCYL ASPARAGINE GLYCYL ASPARTIC ACID AND BIURET BASE BY EREPSIN

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