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首页> 美国卫生研究院文献>Cancer Science >The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects
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The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects

机译：低血清胃蛋白酶原水平在日本人群中检测与广泛性慢性胃炎相关的胃癌的意义

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Serum pepsinogen levels were measured in 137 stomach cancer patients and compared with those of 288 normal cancer‐free subjects. The serum pepsinogen levels of stomach cancer patients, especially pepsinogen I and the pepsinogen I/pepsinogen II ratio were significantly lower than those of normal controls and correlated well with the extent of chronic gastritis associated with the cancerous stomach. These results were in good accordance with the results of previous studies indicating that the cancer derived from the stomach where chronic gastritis/intestinal metaplasia is extensive. The high sensitivity and specificity of this non‐invasive serum test to detect chronic gastritis suggested the possibility of its application to the mass screening of stomach cancer.
机译：测量了137例胃癌患者的血清胃蛋白酶原水平，并与288例无癌的正常人群进行了比较。胃癌患者的血清胃蛋白酶原水平，尤其是胃蛋白酶原I和胃蛋白酶原I /胃蛋白酶原II的比例显着低于正常对照组，并且与与胃癌相关的慢性胃炎的程度密切相关。这些结果与以前的研究结果非常吻合，表明癌症源自于慢性胃炎/肠上皮化生广泛的胃。这项非侵入性血清测试可检测慢性胃炎的高灵敏度和特异性表明，其可用于胃癌的大规模筛查。

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