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首页> 美国卫生研究院文献>Journal of Inflammation (London England) >Annexin-A1 peptide down-regulates the leukocyte recruitment and up-regulates interleukin-10 release into lung after intestinal ischemia-reperfusion in mice
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Annexin-A1 peptide down-regulates the leukocyte recruitment and up-regulates interleukin-10 release into lung after intestinal ischemia-reperfusion in mice

机译：小鼠肠缺血-再灌注后Annexin-A1肽下调白细胞募集并上调白介素10释放入肺

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BackgroundIntestinal ischemia/reperfusion (IR) injury is a serious and triggering event in the development of remote organ dysfunction, from which the lung is the main target. This condition is characterized by intense neutrophil recruitment, increased microvascular permeability. Intestinal IR is also responsible for induction of adult respiratory distress syndrome, the most serious and life-threatening form of acute lung injury. The purpose of this study was to investigate the effect of annexin-A1 protein as an endogenous regulator of the organ remote injury induced by intestinal ischemia/reperfusion. Male C57bl/6 mice were subjected to intestinal ischemia, induced by 45 min occlusion of the superior mesenteric artery, followed by reperfusion.
机译：背景肠缺血/再灌注（IR）损伤是远端器官功能障碍发展中的一个严重触发事件，肺是主要目标。这种情况的特征是强烈的中性粒细胞募集，微血管通透性增加。肠道IR还负责诱发成人呼吸窘迫综合征，这是最严重且威胁生命的急性肺损伤形式。这项研究的目的是调查膜联蛋白A1蛋白作为肠缺血/再灌注所致器官远端损伤的内源性调节剂的作用。雄性C57bl / 6小鼠经历肠缺血，由肠系膜上动脉闭塞45分钟诱导，然后再灌注。

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