• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity
【2h】

Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity

机译：小脑浦肯野细胞以恒定的速率码控制眼球运动该速率码对于尖峰不规则性是不变的

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The rate and temporal pattern of neural spiking each have the potential to influence computation. In the cerebellum, it has been hypothesized that the irregularity of interspike intervals in Purkinje cells affects their ability to transmit information to downstream neurons. Accordingly, during oculomotor behavior in mice and rhesus monkeys, mean irregularity of Purkinje cell spiking varied with mean eye velocity. However, moment-to-moment variations revealed a tight correlation between eye velocity and spike rate, with no additional information conveyed by spike irregularity. Moreover, when spike rate and irregularity were independently controlled using optogenetic stimulation, the eye movements elicited were well-described by a linear population rate code with 3–5 ms temporal precision. Biophysical and random-walk models identified biologically realistic parameter ranges that determine whether spike irregularity influences responses downstream. The results demonstrate cerebellar control of movements through a remarkably rapid rate code, with no evidence for an additional contribution of spike irregularity.
机译：神经峰值的速率和时间模式都有可能影响计算。在小脑中，已经假设浦肯野细胞中突突间隔的不规则性会影响它们向下游神经元传递信息的能力。因此，在小鼠和恒河猴的动眼行为期间，浦肯野细胞突刺的平均不规则性随平均眼速度而变化。然而，瞬间之间的变化揭示了眼球速度和峰值频率之间的紧密相关性，而峰值不规则性没有传达其他信息。此外，当使用光遗传学刺激独立控制尖峰频率和不规则度时，所引起的眼球运动可以通过线性人口速率代码（时间精度为3–5 ms）很好地描述。生物物理模型和随机游走模型确定了生物学上现实的参数范围，这些参数范围决定了峰值不规则性是否影响下游响应。结果表明小脑运动通过非常快的速率代码控制，没有证据表明峰值不规则性的其他贡献。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号