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首页> 美国卫生研究院文献>ACS Omega >Influence of Branched Polyester Chains on the EmissionBehavior of Dipyridamole Molecule and Its Biosensing Ability
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Influence of Branched Polyester Chains on the EmissionBehavior of Dipyridamole Molecule and Its Biosensing Ability

机译：聚酯支链对排放的影响双嘧达莫分子的行为及其生物传感能力

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摘要

Toward the development of the smart biosensing drug carrier, integration of dye molecules with polymeric chain has been an emerging method in recent years. In this perspective, dipyridamole (Dip)-based branched poly(l-lactide) (PLLA) and branched polycaprolactone (PCL) have been synthesized by ring-opening polymerization. After polymerization, the influence of the polyester chains on the Dip emission behavior has been studied systematically in this work. Dip–PLLA has undergone C=O···N=C interaction in ground stage, leading to intramolecular charge transfer in the excited state. Limited availability of the C=O in PCL chains resists such interactions with Dip molecule. So, this structural availability of the C=O group in the polymeric chains influences the color change between Dip–PLLA (green fluorescence) and Dip–PCL (blue fluorescence). To visualize the biosensing ability of Dip–PLLA and Dip–PCL, hollow microspheres have been prepared by the double-emulsion solvent evaporation method, and the prepared microspherescells uptake has been visualized by fluorescence imaging.
机译：随着智能生物传感药物载体的发展，染料分子与聚合物链的整合已成为近年来的新兴方法。从这个角度出发，通过开环聚合合成了基于双嘧达莫（Dip）的支链聚（1-丙交酯）（PLLA）和支链聚己内酯（PCL）。聚合后，已在这项工作中系统地研究了聚酯链对Dip发射行为的影响。在基期，Dip–PLLA经历了C = O···N = C相互作用，从而在激发态下导致分子内电荷转移。 PCL链中C = O的有限可用性可抵抗与Dip分子的这种相互作用。因此，聚合物链中C = O基团的这种结构可用性影响Dip-PLLA（绿色荧光）和Dip-PCL（蓝色荧光）之间的颜色变化。为了可视化Dip–PLLA和Dip–PCL的生物传感能力，通过双乳液溶剂蒸发法制备了中空微球，并制备了微球细胞摄取已通过荧光成像可视化。

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