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Improvements and reproducibility of an optimal grazing-incidence position method to L-shell x-ray fluorescence measurements of lead in bone and soft tissue phantoms

机译：最佳掠入射位方法对骨和软组织体模中铅的L壳X射线荧光测量的改进和重现性

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摘要

L-shell x-ray fluorescence (LXRF) is a non-invasive approach to lead (Pb) concentration measurements in human bone. The method is based on the detection of the characteristic x-ray photons of Pb at 10.5 and 12.6 keV and experimental studies were designed to perform in vivo human bone Pb measurements. In later studies, however, the initial LXRF methodology was shown to have poor accuracy and precision. In a recent publication, we investigated an optimal grazing-incidence position (OGIP) approach using a submillimeter x-ray beam from an integrated x-ray tube and polycapillary x-ray lens table-top system. The OGIP method effectively reduced the x-ray scatter and produced a Pb detection limit of ~5 μg/g for a 2 mm soft tissue phantom thickness. In this study, the OGIP methodology was improved by using 10 s x-ray spectra acquisitions at sequential positions 0.5 mm apart. The measured Sr Kα peak height versus position data was used to spectroscopically identify the bone phantom and the OGIP. The data was fitted with the analytical convolution between a Gaussian and an exponential decay. The position corresponding to the maximum of the fitted convolution function was then selected as the OGIP. Four phantom sets were used. A cylindrical plaster-of-Paris bone phantom doped with Pb in a concentration of 74 μg/g was used as a bare bone phantom or with one of the three overlying polyoxymethylene cylindrical shell soft tissue phantoms of 1, 2, and 3 mm thickness. The reproducibility of the OGIP method was assessed in five independent trials using each of the four phantom sets. The coefficient of variation (COV) percentage values of the Sr Kα peak height measurements were below 5%. The new procedure decreased by more than threefold the duration and radiation dose of the earlier approach.
机译：L壳X射线荧光（LXRF）是一种非侵入性方法，用于测量人骨中的铅（Pb）浓度。该方法基于对10.5 keV和12.6 keV的Pb的特征性X射线光子的检测，并设计了进行体内人骨Pb测量的实验研究。但是，在以后的研究中，最初的LXRF方法显示出较差的准确性和精密度。在最近的出版物中，我们使用来自集成x射线管和多毛细管x射线镜头台式系统的亚毫米x射线束研究了最佳掠入射位置（OGIP）方法。 OGIP方法有效降低了X射线散射，对于2 mm的软组织体模厚度，产生的Pb检测极限为〜5μg/ g。在这项研究中，通过在相距0.5 mm的连续位置上使用10 s X射线光谱采集来改进OGIP方法。测得的SrKα峰高与位置数据的关系用于光谱鉴定骨模和OGIP。数据拟合了高斯和指数衰减之间的解析卷积。然后选择与拟合卷积函数的最大值相对应的位置作为OGIP。使用了四个幻影组。用浓度为74μg/ g的Pb掺杂的圆柱形巴黎石膏骨幻影用作裸骨幻影，或与厚度为1、2和3 mm的三个上覆聚甲醛圆柱壳软组织幻影之一。 OGIP方法的重现性是在使用四个模型组中的每一个进行的五个独立试验中进行评估的。 SrKα峰高测量值的变异系数（COV）百分比值低于5％。新程序将持续时间和辐射剂量减少了三倍以上。

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    Mihai R. Gherase; Summer Al-Hamdani;

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  • 年(卷),期 -1(4),6
  • 年度 -1
  • 页码 065024
  • 总页数 27
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