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首页> 美国卫生研究院文献>other >Does the Clock Tick Slower or Faster in Parkinson’s Disease? – Insights Gained From the Synchronized Tapping Task
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Does the Clock Tick Slower or Faster in Parkinson’s Disease? – Insights Gained From the Synchronized Tapping Task

机译：帕金森氏病的时钟刻度变慢还是变快？ –同步点击任务获得的见解

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The rhythm of the internal clock is considered to be determined by the basal ganglia, with some studies suggesting slower internal clock in Parkinson’s disease (PD). However, patients may also show motor hastening when they walk (festination) or are engaged in repetitive tapping, indicating faster ticking of the internal clock. Is the internal clock slower or faster in PD? The purpose of this study was to answer this question, i.e., how fast and slow a rhythm they can synchronize with, especially with reference to the limit of sensorimotor synchronization or temporal integration, representing the threshold of slower pace they can entrain into their motor actions, which is known to lie between 2 and 3 s in normal subjects but not yet studied in PD. We employed a synchronized tapping task that required subjects to tap the key in synchrony with repetitive tones at fixed interstimulus intervals (ISI) between 200 and 4800 ms. Twenty normal subjects and sixteen PD patients were enrolled, who were classified into early and advanced PD groups by UPDRS-III (early: 15 or less, advanced: more than 15). The ISI at which the response changes from synchronizing with the tones to lagging behind them was considered to be the limit of temporal integration. Early PD patients responded ahead of the tones (negative asynchrony), which became more apparent with repeated tapping. This suggested “faster” ticking clock even in the presence of the pacing tones. In normal subjects, the limit of temporal integration was around 2–3 s: below this, subjects could synchronize with the tones, while above it they had difficulty in synchronization. In early PD patients, the limit of temporal integration was significantly longer than in normal subjects, pointing to their enhanced ability to synchronize also with slower paces of tones, but advanced PD patients had significantly shortened limits, suggesting that advanced patients lost this ability. In conclusion, the limit of temporal integration is initially longer but gets shorter as the disease progresses. It can be explained by the hastening of the internal clock at the earlier stages of PD, followed by the loss of temporal integration.
机译：内部时钟的节奏被认为是由基底神经节决定的，一些研究表明，帕金森氏病（PD）的内部时钟较慢。但是，患者在行走（目的地）或进行重复敲击时也可能会出现运动加速，表明内部时钟的滴答声更快。 PD中的内部时钟变慢还是变快？这项研究的目的是回答这个问题，即，他们可以与之同步的节奏有多快和多慢，特别是在感觉运动同步或时间整合的极限方面，代表了他们可以卷入运动动作的较慢步伐的阈值，已知在正常受试者中处于2到3 s之间，但尚未在PD中进行研究。我们采用了同步敲击任务，要求受试者以200至4800毫秒之间的固定激励间隔（ISI）与重复音调同步敲击琴键。纳入20名正常受试者和16名PD患者，根据UPDRS-III将其分为早期PD组和晚期PD组（早期：15名或以下，晚期：15名以上）。响应从与音调同步变为滞后于其变化的ISI被认为是时间积分的限制。早期的PD患者会在音调之前做出反应（负异步），这种情况在反复敲击时变得更加明显。即使出现起搏音调，这也建议“更快”的滴答时钟。在正常受试者中，时间整合的极限约为2-3 s：在此之下，受试者可以与音调同步，而在高于此值时，他们很难同步。在早期的PD患者中，时间整合的极限显着长于正常受试者，这表明他们的同步能力增强，并且与较慢的音调同步，但晚期PD患者的极限显着缩短，表明晚期患者丧失了这种能力。总之，暂时性整合的极限起初较长，但随着疾病的进展而变短。可以通过在PD的早期阶段加速内部时钟，然后损失时间积分来解释。

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