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Curcumin as Treatment for Bladder Cancer: A Preclinical Study of Cyclodextrin-Curcumin Complex and BCG as Intravesical Treatment in an Orthotopic Bladder Cancer Rat Model

机译：姜黄素治疗膀胱癌的研究：环糊精-姜黄素复合物和卡介苗在膀胱原位癌大鼠模型中的膀胱内治疗的临床前研究

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Objective To evaluate the antitumor effect of cyclodextrin-curcumin complex (CDC) on human and rat urothelial carcinoma cells in vitro and to evaluate the effect of intravesical instillations of CDC, BCG, and the combination in vivo in the AY-F344 orthotopic bladder cancer rat model. Curcumin has anticarcinogenic activity on urothelial carcinoma and is therefore under investigation for the treatment of non-muscle invasive bladder cancer. Curcumin and BCG share immunomodulating pathways against urothelial carcinoma.

机译：目的评价环糊精-姜黄素复合物（CDC）对人和大鼠尿路上皮癌细胞的体外抗肿瘤作用，并评价膀胱内注入CDC，BCG及其组合在AY-F344原位膀胱癌大鼠中的作用。模型。姜黄素对尿路上皮癌具有抗癌活性，因此正在研究治疗非肌肉浸润性膀胱癌。姜黄素和卡介苗共享针对尿路上皮癌的免疫调节途径。

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作者
J. Falke; J. Parkkinen; L. Vaahtera; C. A. Hulsbergen-van de Kaa; E. Oosterwijk; J. A. Witjes;
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年(卷),期 -1(2018),-1
年度 -1
页码 9634902
总页数 7
原文格式 PDF
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专利

1. Re: Curcumin as Treatment for Bladder Cancer: A Preclinical Study of Cyclodextrin-Curcumin Complex and BCG as Intravesical Treatment in an Orthotopic Bladder Cancer Rat Model [J] . Chang Sam S. The Journal of Urology . 2019,第5期

机译：Re：姜黄素作为膀胱癌的治疗：环糊精 - 姜黄素复合物和BCG在原位膀胱癌大鼠模型中的膀胱内治疗临床研究
2. A Phase I study of an intravesically administered immunotoxin targeting EpCAM for the treatment of nonmuscle-invasive bladder cancer in BCG-refractory and BCG-intolerant patients [J] . Mark Kowalski, Joycelyn Entwistle, Jeannick Cizeau, Drug Design, Development and Therapy . 2010,第4期

机译：一期研究针对EpCAM的膀胱内免疫毒素治疗BCG难治性和BCG耐受性患者的非肌肉浸润性膀胱癌
3. Antitumor Efficacy of Intravesical BCG, Gemcitabine, Interferon-α and Interleukin-2 as Mono- or Combination-Therapy for Bladder Cancer in an Orthotopic Tumor Model [J] . Zhengwen Xiao, Erich Hanel, Allan Mak, Clinical Medicine Insights: Oncology . 2011,第5期

机译：卡介苗卡介苗，吉西他滨，干扰素-α和白介素-2作为原发性肿瘤模型膀胱癌的单药或联合疗法的抗肿瘤功效
4. Responses to hexyl 5-aminolev ulinate-induced photodynamic treatment in rat bladder cancer model [C] . Carl-Jorgen Arum, Odrun Gederas, Eivind Larsen, Photonic therapeutics and diagnostics VI . 2010

机译：对5-氨基乙酰丙酸戊酸己酯诱导的大鼠膀胱癌光动力治疗的反应
5. Treatment patterns, costs and outcomes of systemic chemotherapy, adjuvant intravesical therapy, and surveillance for urothelial bladder cancer. [D] . Kerrigan, Matthew Charles. 2007

机译：全身化疗，辅助膀胱内治疗和尿路上皮膀胱癌监测的治疗方式，费用和结果。
6. Intravesical ALT-803 and BCG Treatment Reduces Tumor Burden in a Carcinogen Induced Bladder Cancer Rat Model; a Role for Cytokine Production and NK Cell Expansion [O] . Evan Gomes-Giacoia, Makito Miyake, Steve Goodison, -1

机译：膀胱内注射ALT-803和卡介苗治疗可减少致癌物诱发的膀胱癌大鼠模型的肿瘤负担；细胞因子生产和NK细胞扩增的作用。
7. Intravesical ALT-803 and BCG treatment reduces tumor burden in a carcinogen induced bladder cancer rat model; a role for cytokine production and NK cell expansion. [O] . Evan Gomes-Giacoia, Makito Miyake, Steve Goodison, 2014

机译：膀胱内aLT-803和BCG治疗可降低致癌物诱导的膀胱癌大鼠模型的肿瘤负荷;细胞因子产生和NK细胞扩增的作用。

Curcumin as Treatment for Bladder Cancer: A Preclinical Study of Cyclodextrin-Curcumin Complex and BCG as Intravesical Treatment in an Orthotopic Bladder Cancer Rat Model

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