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首页> 美国卫生研究院文献>Journal of Health Population and Nutrition >Plasma arachidonic and docosahexaenoic acids in Tunisian very low birth weight infants: status and association with selected neonatal morbidities
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Plasma arachidonic and docosahexaenoic acids in Tunisian very low birth weight infants: status and association with selected neonatal morbidities

机译：突尼斯极低体重婴儿的血浆花生四烯酸和二十二碳六烯酸：状况和与某些新生儿发病率的关系

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To study plasma arachidonic acid (AA) and docosahexaenoic acid (DHA) status in Tunisian very low birth weight (VLBW) infants and their association with selected neonatal morbidities. A total of 709 VLBW infants and 339 term infants were included. Plasma fatty acids were analyzed using capillary gas chromatography. VLBW infants had significantly (p < 0.001) lower plasma AA (9.44 ± 2.12 vs. 10.8 ± 2.10) and DHA (2.56 ± 0.89 vs. 3.46 ± 1.09) levels, but higher n-6:n-3 ratio (5.58 ± 1.22 vs. 5.17 ± 1.46) than term infants. In VLBW infants, plasma AA and DHA were related to gestational age (r = 0.156; p = 0.001 and r = 0.134; p = 0.003, respectively), birthweight (r = 0.242; p < 0.001 and r = 0.181; p < 0.001, respectively) and head circumference (r = 0.138; p = 0.005 and r = 0.108; p = 0.027, respectively). Infants with respiratory distress syndrome have decreased plasma AA and DHA and those with intraventricular hemorrhage have decreased plasma AA and n-6:n-3 ratio. Sepsis was associated with decreased DHA levels. Plasma long chain polyunsaturated fatty acids status is low in VLBW infants. These deficits may enhance the risk of common neonatal morbidities, rendering their prevention and correction greatly warranted.
机译：目的研究突尼斯极低出生体重（VLBW）婴儿的血浆花生四烯酸（AA）和二十二碳六烯酸（DHA）状况及其与所选新生儿发病率的关系。包括709名VLBW婴儿和339名足月婴儿。使用毛细管气相色谱法分析血浆脂肪酸。 VLBW婴儿的血浆AA（9.44±±2.12比10.8±±2.10）显着（p <0.001）和DHA（2.56±±0.89与3.46±±1.09）降低，但n-6：n-3比（5.58±±1.22）较高相对于足月儿为5.17％±1.46）。在VLBW婴儿中，血浆AA和DHA与胎龄（r = 0.156； p = 0.001和r = 0.134； p = 0.003），出生体重（r = 0.242； p <0.001和r = 0.181； p <0.001）有关。和头围（分别为r = 0.138; p = 0.005和r = 0.108; p = 0.027）。患有呼吸窘迫综合征的婴儿血浆AA和DHA降低，而患有脑室内出血的婴儿血浆AA和n-6：n-3比率降低。败血症与DHA水平降低有关。 VLBW婴儿的血浆长链多不饱和脂肪酸状态低。这些缺陷可能会增加新生儿常见病的风险，因此有必要对其进行预防和纠正。

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