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首页> 美国卫生研究院文献>other >Continuous Change in Membrane and Membrane-Skeleton Organization During Development From Proerythroblast to Senescent Red Blood Cell
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Continuous Change in Membrane and Membrane-Skeleton Organization During Development From Proerythroblast to Senescent Red Blood Cell

机译：从成红细胞到衰老的红细胞发育过程中膜和膜骨架的连续变化

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Within the context of erythropoiesis and the possibility of producing artificial red blood cells (RBCs) in vitro, a most critical step is the final differentiation of enucleated erythroblasts, or reticulocytes, to a fully mature biconcave discocyte, the RBC. Reviewed here is the current knowledge about this fundamental maturational process. By combining literature data with our own experimental evidence we propose that the early phase in the maturation of reticulocytes to RBCs is driven by a membrane raft-based mechanism for the sorting of disposable membrane proteins, mostly the no longer needed transferrin receptor (TfR), to the multivesicular endosome (MVE) as cargo of intraluminal vesicles that are subsequently exocytosed as exosomes, consistently with the seminal and original observation of Johnstone and collaborators of more than 30 years ago (Pan BT, Johnstone RM. Cell. 1983;33:967-978). According to a strikingly selective sorting process, the TfR becomes cargo destined to exocytosis while other molecules, including the most abundant RBC transmembrane protein, band 3, are completely retained in the cell membrane. It is also proposed that while this process could be operating in the early maturational steps in the bone marrow, additional mechanism(s) must be at play for the final removal of the excess reticulocyte membrane that is observed to occur in the circulation. This processing will most likely require the intervention of the spleen, whose function is also necessary for the continuous remodeling of the RBC membrane all along this cell's circulatory life.
机译：在红细胞生成和在体外产生人工红细胞（RBC）的可能性的背景下，最关键的步骤是将去核的成红细胞或网状细胞最终分化为完全成熟的双凹盘状细胞RBC。本文回顾了有关此基本成熟过程的最新知识。通过将文献数据与我们自己的实验证据相结合，我们认为网状细胞成熟为RBC的早期阶段是由基于膜筏的一次性膜蛋白（主要是不再需要的转铁蛋白受体（TfR））分选机制驱动的，作为腔内囊泡的货物运往多囊泡内体（MVE），随后被囊泡吞噬，这与Johnstone及其合作者在三十多年前的开创性和原始观察结果一致（Pan BT，Johnstone RM。Cell。1983; 33：967 -978）。根据惊人的选择性分选过程，TfR成为注定要胞吐的货物，而其他分子，包括最丰富的RBC跨膜蛋白，带3，则完全保留在细胞膜中。还提出，尽管该过程可以在骨髓的成熟阶段中进行，但必须采取其他机制以最终去除循环中观察到的过量网状红细胞膜。这种处理很可能需要脾脏的干预，脾脏的功能对于整个细胞的循环寿命中RBC膜的连续重塑也是必不可少的。

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