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Towards a sustainable bio-based economy: Redirecting primary metabolism to new products with plant synthetic biology

机译:迈向可持续的以生物为基础的经济:利用植物合成生物学将主要代谢重新导向新产品

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摘要

Humans have domesticated many plant species as indispensable sources of food, materials, and medicines. The dawning era of synthetic biology represents a means to further refine, redesign, and engineer crops to meet various societal and industrial needs. Current and future endeavors will utilize plants as the foundation of a bio-based economy through the photosynthetic production of carbohydrate feedstocks for the microbial fermentation of biofuels and bioproducts, with the end goal of decreasing our dependence on petrochemicals. As our technological capabilities improve, metabolic engineering efforts may expand the utility of plants beyond sugar feedstocks through the direct production of target compounds, including pharmaceuticals, renewable fuels, and commodity chemicals. However, relatively little work has been done to fully realize the potential in redirecting central carbon metabolism in plants for the engineering of novel bioproducts. Although our ability to rationally engineer and manipulate plant metabolism is in its infancy, I highlight some of the opportunities and challenges in applying synthetic biology towards engineering plant primary metabolism.
机译:人类已经将许多植物物种驯化为食物,材料和药物的必不可少的来源。合成生物学的曙光时代代表着一种进一步改良,重新设计和改造农作物以满足各种社会和工业需求的手段。当前和未来的努力将通过光合作用生产生物燃料和生物产品的碳水化合物原料的光合作用生产植物,来利用植物作为生物经济的基础,最终目的是减少我们对石化产品的依赖。随着我们技术能力的提高,新陈代谢工程的努力可能会通过直接生产包括药物,可再生燃料和商品化学品在内的目标化合物,将植物的用途扩展到糖类原料之外。但是,为充分认识到重新定向植物中的碳代谢以进行新型生物产品工程化的潜力,所做的工作很少。尽管我们合理地设计和操纵植物代谢的能力尚处于起步阶段,但我强调了将合成生物学应用于植物初生代谢的一些机遇和挑战。

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