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NK/T-cell lymphoma nasal type γδ T-cell lymphoma and CD8-positive epidermotropic T-cell lymphoma—clinical and histopathologic features differential diagnosis and treatment

机译:NK / T细胞淋巴瘤鼻型γδT细胞淋巴瘤和CD8阳性表皮性T细胞淋巴瘤-临床和组织病理学特征鉴别诊断和治疗

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摘要

The cytotoxic lymphomas of the skin constitute a heterogeneous group of rare lymphoproliferative diseases that are derived from mature T cells and natural killer (NK) cells that express cytotoxic molecules (T-cell intracellular antigen-1, granzyme A/B, and perforin). Although frequently characterized by an aggressive course and poor prognosis, these diseases can have variable clinical behavior. This review delivers up-to-date information about the clinical presentation, histopathologic features, differential diagnosis, and therapy of extranodal NK/T-cell lymphoma, nasal type, primary cutaneous gamma delta T-cell lymphoma, and primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma.
机译:皮肤的细胞毒性淋巴瘤由罕见的淋巴增生性疾病组成异质性组,它们来自表达细胞毒性分子(T细胞细胞内抗原-1,颗粒酶A / B和穿孔素)的成熟T细胞和自然杀伤(NK)细胞。尽管这些疾病通常以侵袭性病程和预后不良为特征,但它们的临床行为可能会有所不同。这篇综述提供了有关结外NK / T细胞淋巴瘤,鼻型,原发性皮肤γ-δT细胞淋巴瘤和原发性皮肤CD8 +侵袭性表皮细胞毒性的临床表现,组织病理学特征,鉴别诊断和治疗的最新信息。 T细胞淋巴瘤。

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