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Spared Behavioral Repetition Effects in Alzheimer’s DiseaseLinked to an Altered Neural Mechanism at Posterior Cortex

机译:阿尔茨海默氏病中行为重复的备用效应与后皮质的神经机制改变有关

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摘要

Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect, suggesting that visual cortex may play a role in maintained repetition effects in persons with early AD.
机译:患有阿尔茨海默氏病(AD)的痴呆症患者通常在工作记忆方面表现出不成比例的损伤,但是重复学习的效果相对得以保留。由于AD影响涉及工作记忆和重复效应的大脑区域,因此对该差异的神经基础了解甚少。我们假设后方重复效应可以解释这种差异,这是由于视觉皮层中AD的影响较轻。患有早期AD,轻度遗忘性认知障碍(MCI)和健康对照的参与者执行了具有叠加重复效应的工作记忆任务,同时收集了脑电图以识别保留的重复效应的可能神经机制。患有AD的参与者表现出保留的行为重复作用和后重复作用的改变,表明视觉皮层可能在早期AD患者的维持重复作用中起作用。

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