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首页> 美国卫生研究院文献>other >Response bias and response monitoring: Evidence from healthy older adults and patients with mild Alzheimers disease
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Response bias and response monitoring: Evidence from healthy older adults and patients with mild Alzheimers disease

机译：反应偏倚和反应监测：健康的老年人和轻度阿尔茨海默氏病患者的证据

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Patients with Alzheimer's disease (AD) often exhibit an abnormally liberal response bias in recognition memory tests, responding “old” more frequently than “new.” Investigations have shown patients can to shift to a more conservative response bias when given instructions. We examined if patients with mild AD could alter their response patterns when the ratio of old items is manipulated without explicit instruction. Healthy older adults and AD patients studied lists of words and then were tested in three oldew ratio conditions (30%, 50%, or 70% old items). A subset of participants provided estimates of how many old and new items they saw in the memory test. We demonstrated that both groups were able to change their response patterns without the aid of explicit instructions. Importantly, AD patients were more likely to estimate seeing greater numbers of old than new items, whereas the reverse was observed for older adults. Elevated estimates of old items in AD patients suggest their liberal response bias may be attributed to their reliance on familiarity. We conclude that the liberal response bias observed in AD patients is attributable to their believing that more of the test items are old, and not due to impaired meta-memorial monitoring abilities.
机译：患有阿尔茨海默氏病（AD）的患者通常在识别记忆测试中表现出异常宽松的反应偏见，对“老”的反应比对“新”的反应更频繁。研究表明，在给予指导后，患者可以转向更为保守的反应偏见。我们检查了在没有明确指导的情况下操纵旧物品的比例时，轻度AD患者是否可以改变其反应方式。健康的老年人和AD患者研究单词列表，然后在三种新旧比率条件下（30％，50％或70％旧项目）进行测试。一部分参与者提供了他们在记忆力测试中看到的新旧物品的估计值。我们证明了这两个小组都可以在没有明确指示的情况下改变他们的反应方式。重要的是，AD患者更有可能估计看到的旧物品数量多于新物品，而老年人则相反。对AD患者中旧物品的高估表明他们的自由反应偏倚可能归因于他们对熟悉程度的依赖。我们得出的结论是，在AD患者中观察到的自由反应偏倚归因于他们认为更多的测试项目较旧，而不是由于元记忆监测能力受损所致。

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