首页> 外国专利> antigen peptide or functional fragment thereof, pharmaceutical composition, methods for treating a neurodegenerative disease or disorder such as tauopathy, to induce an immune response in an animal, to diagnose a disease, disorder or condition and a predisposition to disease, disorder or condition, to monitor minimal residual disease in a patient and to predict a patient's receptivity, antibody, test kit, epitope, and cell line.

antigen peptide or functional fragment thereof, pharmaceutical composition, methods for treating a neurodegenerative disease or disorder such as tauopathy, to induce an immune response in an animal, to diagnose a disease, disorder or condition and a predisposition to disease, disorder or condition, to monitor minimal residual disease in a patient and to predict a patient's receptivity, antibody, test kit, epitope, and cell line.

机译:抗原肽或其功能片段,药物组合物,治疗神经退行性疾病或病症如tauopathy,在动物中诱导免疫应答,诊断疾病,病症或病状以及对疾病,病症或病状的易感性的方法,监测患者的最小残留疾病,并预测患者的接受性,抗体,检测试剂盒,表位和细胞系。

摘要

The present invention is related to methods and pharmaceutical compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to pharmaceutical composition comprising an antigenic peptide, particularly an antigenic phospho-peptide mimicking a major pathological phospho-epitope of protein tau, for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease.
机译:本发明涉及用于治疗和诊断用途的方法和药物组合物,用于治疗由神经原纤维缠结引起或与之相关的疾病和病症。特别地,本发明涉及药物组合物,其包含抗原性肽,特别是模仿蛋白质tau的主要病理性磷酸表位的抗原性磷酸肽,用于治疗和诊断用于包括阿尔茨海默氏病在内的疾病。

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