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首页> 美国卫生研究院文献>other >Evaluation of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) in pure mineral hydrocarbon-based cosmetics and cosmetic raw materials using1H NMR spectroscopy
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Evaluation of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) in pure mineral hydrocarbon-based cosmetics and cosmetic raw materials using1H NMR spectroscopy

机译：使用纯矿物烃基化妆品和化妆品原料评估矿物油饱和烃（MOSH）和矿物油芳烃（MOAH）1H NMR光谱

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摘要

Mineral hydrocarbons consist of two fractions, mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH). MOAH is a potential public health hazard because it may include carcinogenic polycyclic compounds. In the present study, 400 MHz nuclear magnetic resonance (NMR) spectroscopy was introduced, in the context of official controls, to measure MOSH and MOAH in raw materials or pure mineral hydrocarbon final products (cosmetics and medicinal products). Quantitative determination (qNMR) has been established using the ERETIC methodology (electronic reference to access in vivo concentrations) based on the PULCON principle (pulse length based concentration determination). Various mineral hydrocarbons (e.g., white oils, paraffins or petroleum jelly) were dissolved in deuterated chloroform. The ERETIC factor was established using a quantification reference sample containing ethylbenzene and tetrachloronitrobenzene. The following spectral regions were integrated: MOSH δ 3.0 – 0.2 ppm and MOAH δ 9.2 - 6.5, excluding solvent signals. Validation showed a sufficient precision of the method with a coefficient of variation <6% and a limit of detection <0.1 g/100 g. The applicability of the method was proven by analysing 27 authentic samples with MOSH and MOAH contents in the range of 90-109 g/100 g and 0.02-1.10 g/100 g, respectively. It is important to distinguish this new NMR-approach from the hyphenated liquid chromatography-gas chromatography methodology previously used to characterize MOSH/MOAH amounts in cosmetic products. For mineral hydrocarbon raw materials or pure mineral hydrocarbon-based cosmetic products, NMR delivers higher specificity without any sample preparation besides dilution. Our sample survey shows that previous methods may have overestimated the MOAH amount in mineral oil products and opens new paths to characterize this fraction. Therefore, the developed method can be applied for routine monitoring of consumer products aiming to minimize public health risks.
机译：矿物烃包括两部分，矿物油饱和烃（MOSH）和矿物油芳烃（MOAH）。 MOAH是潜在的公共健康危害，因为它可能包含致癌的多环化合物。在本研究中，在官方控制的背景下，引入了400 MHz核磁共振波谱法，以测量原材料或纯矿物碳氢化合物最终产品（化妆品和药品）中的MOSH和MOAH。基于PULCON原理（基于脉冲长度的浓度测定），使用ERETIC方法（电子参考以获取体内浓度）已经建立了定量测定（qNMR）。将各种矿物烃（例如，白油，石蜡或凡士林）溶解在氘代氯仿中。使用包含乙苯和四氯硝基苯的定量参考样品建立ERETIC因子。整合了以下光谱区域：MOSHδ3.0 – 0.2 ppm和MOAHδ9.2-6.5，不包括溶剂信号。验证表明该方法具有足够的精度，变异系数<6％，检出限<0.1 g / 100 g。该方法的适用性通过分析27个真实样品而得到证实，这些样品的MOSH和MOAH含量分别为90-109 g / 100 g和0.02-1.10 g / 100 g。将这种新的NMR方法与以前用于表征化妆品中MOSH / MOAH量的联用液相色谱-气相色谱方法相区别很重要。对于矿物碳氢化合物原料或纯矿物碳氢基化妆品，NMR除了稀释外无需任何样品制备即可提供更高的特异性。我们的样本调查显示，以前的方法可能高估了矿物油产品中的MOAH含量，并开辟了表征这一馏分的新途径。因此，所开发的方法可用于日常消费品监测，以最大程度地降低公共健康风险。

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