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New approach to generating insights for aging research based on literature mining and knowledge integration

机译:基于文献挖掘和知识整合为老化研究生成见解的新方法

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摘要

The proportion of the elderly population in most countries worldwide is increasing dramatically. Therefore, social interest in the fields of health, longevity, and anti-aging has been increasing as well. However, the basic research results obtained from a reductionist approach in biology and a bioinformatic approach in genome science have limited usefulness for generating insights on future health, longevity, and anti-aging-related research on a case by case basis. We propose a new approach that uses our literature mining technique and bioinformatics, which lead to a better perspective on research trends by providing an expanded knowledge base to work from. We demonstrate that our approach provides useful information that deepens insights on future trends which differs from data obtained conventionally, and this methodology is already paving the way for a new field in aging-related research based on literature mining. One compelling example of this is how our new approach can be a useful tool in drug repositioning.
机译:世界上大多数国家的老年人口比例正在急剧增加。因此,在健康,长寿和抗衰老领域中的社会兴趣也在增加。但是,从生物学的还原论方法和基因组科学的生物信息学方法获得的基础研究结果,对于逐案分析未来健康,寿命和抗衰老相关研究的见解的实用性有限。我们提出了一种使用我们的文献挖掘技术和生物信息学的新方法,该方法通过提供扩展的知识基础来更好地研究趋势。我们证明,我们的方法提供了有用的信息,可加深对与常规数据不同的未来趋势的洞察力,并且该方法论已经为基于文献挖掘的衰老相关研究的新领域铺平了道路。一个令人信服的例子是我们的新方法如何成为药物重新定位的有用工具。

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