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Should first-line empiric treatment strategies cover coagulase-negative staphylococcal infections in severely malnourished or HIV-infected children in Kenya?

机译:一线经验治疗策略是否应该涵盖肯尼亚严重营养不良或感染HIV的儿童的凝固酶阴性葡萄球菌感染?

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摘要

BackgroundBloodstream infection is a common cause of morbidity in children aged <5 years in developing countries. In studies reporting bacteremia in Africa, coagulase-negative Staphylococci (CoNS) are commonly isolated. However, it is currently unclear whether children who are highly susceptible to infection because of severe acute malnutrition (SAM) or HIV should be treated with antimicrobials specifically to cover CoNS. We aimed to determine the clinical significance of CoNS amongst children admitted to a rural hospital in Kenya in relation to nutritional and HIV status.
机译:背景技术在发展中国家,血液感染是<5岁儿童发病的常见原因。在非洲报告细菌血症的研究中,通常分离出凝固酶阴性葡萄球菌(CoNS)。但是,目前尚不清楚是否应对因严重急性营养不良(SAM)或HIV而高度易感染的儿童进行专门覆盖CoNS的抗生素治疗。我们旨在确定在肯尼亚农村医院住院的儿童中CoNS的营养和艾滋病毒状况的临床意义。

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