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Characterization of lipid profile by nuclear magnetic resonance spectroscopy (1H NMR) of metabolically healthy obese women after weight loss with Mediterranean diet and physical exercise

机译：通过地中海饮食和体育锻炼减肥后代谢健康的肥胖女性的核磁共振波谱（1H NMR）表征脂质分布

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Obesity is associated with an atherogenic lipid profile. No data exists on lipoprotein particle profiles in metabolically healthy obese (MHO) individuals. Our aim is to characterize lipoprotein size, particle, and subclass concentrations in MHO women after 3 months of weight loss through dietary restriction and physical exercise.A total of 115 nondiabetic women (aged 35–55 years) with a body mass index (BMI) of 30 to 40 kg/m2 and ≤1 of the following criteria: blood pressure ≤135/85 mm Hg, fasting plasma glucose ≤100 mg/dL, HDL-cholesterol ≤50 mg/dL, and triglycerides ≤150 mg/dL were included. After 3 months of intensive lifestyle modification (Mediterranean diet and physical exercise), they were classified according to their weight loss: <5%, ≥5% to <10%, and ≥10%. Lipoprotein size, particle, and subclass concentrations were measured using 1H NMR.The final sample, after dropouts, comprised 104 women (age: 44.4 ± 3.7 years, BMI: 36.3 ± 4.7 kg/m2), of whom 47 (45.2%), 27 (26%), and 30 (28.8%) lost <5%, ≥5% to <10%, and ≥10% of baseline body weight, respectively. All participants experienced significant weight loss and decreases in BMI. The lipid profiles showed an increase in small, medium, and large very low density lipoprotein (VLDL) particles in all groups of study with the exception of small VLDL particles in women with ≥10% of weight loss, in which it decreased. The number of VLDL particles decreased in women who had ≥10% weight loss. On the other hand, we detected a decrease in all low density lipoprotein (cLDL) and high density lipoprotein (cHDL) concentrations.These results indicate that intensive lifestyle modification alters lipid profiles. In particular, it decreases small LDL and HDL particle numbers and does not increase medium or large HDL particles numbers.
机译：肥胖与动脉粥样硬化性脂质状况有关。在代谢健康的肥胖（MHO）个体中，脂蛋白颗粒概况尚无数据。我们的目标是通过饮食限制和体育锻炼来减轻体重减轻3个月的MHO妇女的脂蛋白大小，颗粒和亚类浓度。共有115名体重指数（BMI）的非糖尿病妇女（年龄35-55岁） 30至40 kg / m 2 且≤1的以下标准：血压≤135/ 85 mm Hg，空腹血糖≤100mg / dL，HDL胆固醇≤50mg / dL，甘油三酯≤150mg / dL。经过3个月的强化生活方式修改（地中海饮食和体育锻炼）后，根据体重减轻对他们进行了分类：<5％，≥5％至<10％和≥10％。使用 1 1 H NMR测量脂蛋白的大小，颗粒和亚类浓度。辍学后的最终样本包括104名女性（年龄：44.4±3.7岁，BMI：36.3±4.7 kg / m 2 ），其中基线体重的<5％，≥5％至<10％和≥10％，其中47（45.2％），27（26％）和30（28.8％），分别。所有参与者都经历了明显的体重减轻和BMI降低。在所有研究组中，脂质分布均显示出较小，中等和较大的极低密度脂蛋白（VLDL）颗粒增加，体重减轻≥10％的女性中较小的VLDL颗粒除外，其下降趋势。体重减轻≥10％的女性VLDL颗粒数量减少。另一方面，我们检测到所有低密度脂蛋白（cLDL）和高密度脂蛋白（cHDL）浓度均下降，这些结果表明强化的生活方式改变会改变血脂谱。特别是，它减少了小LDL和HDL颗粒数量，而没有增加中等或大HDL颗粒数量。

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