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Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens

机译：在健康的老年男性中通过饮食中硒和辅酶Q10的补充循环microRNA的显着变化。瑞典老年人中一项前瞻性随机双盲安慰剂对照试验的亚组分析

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BackgroundSelenium and coenzyme Q10 is essential for important cellular functions. A low selenium intake is reported from many European countries, and the endogenous coenzyme Q10 production is decreasing in the body with increasing age. Supplementation with selenium and coenzyme Q10 in elderly have shown reduced cardiovascular mortality and reduced levels of markers of inflammation. However, microRNA analyses could give important information on the mechanisms behind the clinical effects of supplementation.

机译：背景硒和辅酶Q10对于重要的细胞功能至关重要。据报道，许多欧洲国家的硒摄入量较低，并且随着年龄的增长，体内内源性辅酶Q10的产量正在下降。老年人补充硒和辅酶Q10可以降低心血管疾病的死亡率并降低炎症标志物的水平。但是，microRNA分析可以提供有关补充临床作用背后机制的重要信息。

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Urban Alehagen; Peter Johansson; Jan Aaseth; Jan Alexander; Dick Wågsäter;
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年(卷),期 -1(12),4
年度 -1
页码 e0174880
总页数 18
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1. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens [J] . AlehagenU., JohanssonP., Bj?rnstedtM., International Journal of Cardiology . 2013,第5期

机译：硒和辅酶Q10联合补充后，心血管疾病死亡率和N末端proBNP降低：瑞典老年人中一项为期5年的前瞻性随机双盲安慰剂对照试验
2. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens [J] . AlehagenU., JohanssonP., Bj?rnstedtM., International Journal of Cardiology . 2013,第5期

机译：硒和辅酶Q10联合补充后，心血管疾病死亡率和N末端proBNP降低：瑞典老年人中一项为期5年的前瞻性随机双盲安慰剂对照试验
3. Less increase of copeptin and MR-proADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens [J] . Alehagen Urban, Aaseth Jan, Johansson Peter BioFactors . 2015,第6期

机译：硒和辅酶Q10联合干预后，肽素和MR-proADM的增加较少：瑞典老年人中一项为期4年的前瞻性随机双盲安慰剂对照试验的结果
4. Nutraceutical Supplementation: Effect of a Fermented Papaya Preparation on Redox Status and DNA Damage in Healthy Elderly Individuals and Relationship with GSTM1 Genotype A Randomized, Placebo-Controlled, Cross-Over Study [C] . FRANCESO MAROTTA, MARK WEKSLER, YASUHIRO NAITO, International Association of Biomedical Gerontology International . 2006

机译：Nutraceuticalutication：发酵番木瓜对健康老年人的氧化还原状态和DNA损伤的影响与GSTM1基因型A随机，安慰剂控制，交叉研究
5. Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens [O] . Urban Alehagen, Jan Aaseth, Peter Johansson 2010

机译：硒和辅酶Q10补充四年后10年心血管疾病死亡率降低：一项针对老年人的随机双盲安慰剂对照试验的随访结果
6. Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens [O] . Alehagen, Urban, Johansson, Peter, Aaseth, Jan, 2017

机译：在健康的老年男性中，通过饮食中硒和辅酶Q10的补充，循环microRNA的显着变化。瑞典老年人中一项前瞻性随机双盲安慰剂对照试验的亚组分析

Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens

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