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首页> 外文会议>International Association of Biomedical Gerontology International >Nutraceutical Supplementation: Effect of a Fermented Papaya Preparation on Redox Status and DNA Damage in Healthy Elderly Individuals and Relationship with GSTM1 Genotype A Randomized, Placebo-Controlled, Cross-Over Study
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Nutraceutical Supplementation: Effect of a Fermented Papaya Preparation on Redox Status and DNA Damage in Healthy Elderly Individuals and Relationship with GSTM1 Genotype A Randomized, Placebo-Controlled, Cross-Over Study

机译：Nutraceuticalutication：发酵番木瓜对健康老年人的氧化还原状态和DNA损伤的影响与GSTM1基因型A随机，安慰剂控制，交叉研究

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Our study group consisted of 54 elderly patients without major invalidating diseases who were randomly divided into two fully matched groups. Group A was given a certified fermented papaya preparation 9 g/day by mouth, while group B received placebo. Treatment was carried out in a cross-over manner with a 3-month supplementation followed by a 6-week washout period. Blood samples were drawn at entry and on a monthly basis to check routine parameters, redox status, and 8-OHdG in circulating leukocyte DNA. Polymorphism analysis of GSTM1 was carried out as well. The glutathune-S transferase M1 (GSTM1) genotype was null (—) in 40% and 46% of groups A and B, respectively. GSTM1 (—) smokers had a significantly higher level of plasma DNA adducts and leukocytes level of 8-OHdG than their GSTM1 (+) counterparts (P < 0.01). There was a weak correlation between cigarettes smoked/day and DNA adduct (r: 0.61, P < 0.05), which also correlated with antioxidant concentrations, but only in GSTM1 (—) smokers (P < 0.01). The fermented papaya preparation (FPP)-supplemented group showed a significant enhancement of the antioxidant protection (P < 0.01 vs. A) within the subgroups with GSTM1 (—) and of plasma DNA adduct, irrespective of the GSTM1 genotype. Only the GSTM1 (-) subgroup was the one that, under FPP treatment, increased lymphocyte 8-OHdG (P < 0.01). Such preliminary data show that FPP is a promising nutraceutical for improving antioxidant-defense in elderly patients even without any overt antioxidant-deficiency state while helping explain some inconsistent results of prior interventional studies.
机译：我们的研究组包括54例老年无重大疾病无效谁被随机分为两个完全匹配组。基团A被赋予了发酵认证木瓜制备9克/由口天，而B组接受安慰剂。处理在交叉的方式与3个月的补充接着是6周的清除期进行。血液样品在进入和按月抽取检查循环白细胞DNA常规参数，氧化还原状态，和8羟基脱氧鸟苷。 GSTM1基因多态性分析进行为好。所述glutathune-S转移酶M1（GSTM1）基因型为空 - 分别在40％和基团A的46％和B，（）。 GSTM1（ - ）吸烟者血浆DNA加合物的一个显著更高水平和白细胞的8-OHdG比它们的GSTM1（+）对应物（P <0.01）的水平。有烟熏/天和DNA加合物的香烟之间的弱相关性（r：0.61，P <0.05），这也与抗氧化剂浓度相关，但仅在GSTM1（ - ）吸烟者（P <0.01）。发酵木瓜制备（FPP）-supplemented组显示出子组内的抗氧化保护（P <0.01，相对于A）与GSTM1的显著增强（ - ）和血浆DNA加合物，不论GSTM1基因型。只有GSTM1（ - ）组是一个是，根据FPP治疗，增加的淋巴细胞的8-OHdG（P <0.01）。这样的初步数据显示，FPP是一个有前途的保健品对改善老年患者的抗氧化防御即使没有同时帮助解释之前介入研究的一些结果不一致任何明显的抗氧化剂不足的状态。

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