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MEDIATOR18 and MEDIATOR20 confer susceptibility to Fusarium oxysporum in Arabidopsis thaliana

机译:MEDIATOR18和MEDIATOR20使拟南芥中的尖孢镰刀菌易感性

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摘要

The conserved protein complex known as Mediator conveys transcriptional signals by acting as an intermediary between transcription factors and RNA polymerase II. As a result, Mediator subunits play multiple roles in regulating developmental as well as abiotic and biotic stress pathways. In this report we identify the head domain subunits MEDIATOR18 and MEDIATOR20 as important susceptibility factors for Fusarium oxysporum infection in Arabidopsis thaliana. Mutants of MED18 and MED20 display down-regulation of genes associated with jasmonate signaling and biosynthesis while up-regulation of salicylic acid associated pathogenesis related genes and reactive oxygen producing and scavenging genes. We propose that MED18 and MED20 form a sub-domain within Mediator that controls the balance of salicylic acid and jasmonate associated defense pathways.
机译:被称为介体的保守蛋白复合物通过充当转录因子和RNA聚合酶II之间的中介来传递转录信号。结果,介体亚基在调节发育以及非生物和生物应激途径中发挥多种作用。在此报告中,我们确定头域亚基MEDIATOR18和MEDIATOR20是拟南芥中尖孢镰刀菌感染的重要易感性因子。 MED18和MED20的突变体显示与茉莉酸信号传导和生物合成相关的基因下调,而与水杨酸相关的发病相关基因以及活性氧产生和清除基因的上调。我们建议MED18和MED20在介体内形成一个子域,该子域控制水杨酸和茉莉酸相关防御途径的平衡。

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