首页> 美国卫生研究院文献>other >Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN Patients with Intermittent Claudication Injected with ALDH Bright Cells (PACE) Trial

【2h】

Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN Patients with Intermittent Claudication Injected with ALDH Bright Cells (PACE) Trial

机译：细胞疗法对周围动脉疾病运动表现和肢体灌注的评估：间歇性lau行的CCTRN患者注射ALDH亮细胞（PACE）试验

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

BackgroundAtherosclerotic peripheral artery disease (PAD) affects 8–12% of Americans over 65 and is associated with a major decline in functional status, increased myocardial infarction and stroke rates, and increased risk of ischemic amputation. Current treatment strategies for claudication have limitations. PACE is an NHLBI-sponsored, randomized, double-blind, placebo-controlled phase 2, exploratory clinical trial designed to assess safety and efficacy of autologous bone marrow–derived aldehyde dehydrogenase bright (ALDHbr) cells in PAD patients and to explore associated claudication physiologic mechanisms.

机译：背景动脉粥样硬化性外周动脉疾病（PAD）影响65岁以上的美国人中的8–12％，并且与功能状态的严重下降，心肌梗塞和中风发生率的增加以及缺血性截肢的风险增加有关。当前的lau行治疗策略有局限性。 PACE是一项由NHLBI赞助，随机，双盲，安慰剂对照的2期探索性临床试验，旨在评估自体骨髓源性醛脱氢酶亮（ALDHbr）细胞在PAD患者中的安全性和有效性，并探讨相关的lau行生理机制。

著录项

期刊名称 other
作者
Emerson C. Perin; Michael P. Murphy; Keith L. March; Roberto Bolli; John Loughran; Phillip C. Yang; Nicholas J. Leeper; Ronald L. Dalman; Jason Alexander; Timothy D. Henry; Jay H. Traverse; Carl J. Pepine; R. David Anderson; Scott Berceli; James T. Willerson; Raja Muthupillai; Amir Gahremanpour; Ganesh Raveendran; Omaida Velasquez; Joshua M. Hare; Ivonne Hernandez Schulman; Vijaykumar S. Kasi; William R. Hiatt; Bharath Ambale-Venkatesh; João A. Lima; Doris A. Taylor; Micheline Resende; Adrian P. Gee; April G. Durett; Jeanette Bloom; Sara Richman; Patricia G’Sell; Shari Williams; Fouzia Khan; Elsie Gyang Ross; Michelle R. Santoso; JoAnne Goldman; Dana Leach; Eileen Handberg; Benjamin Cheong; Nichole Piece; Darcy DiFede; Barb Bruhn-Ding; Emily Caldwell; Judy Bettencourt; Dejian Lai; Linda Piller; Lara Simpson; Michelle Cohen; Shelly L. Sayre; Rachel W. Vojvodic; Lem Moyé; Ray F. Ebert; Robert D. Simari; Alan T. Hirsch;
展开▼
作者单位

展开▼
年(卷),期 -1(135),15
年度 -1
页码 1417–1428
总页数 22
原文格式 PDF
正文语种
中图分类
关键词
cell therapy vascular disease magnetic resonance imaging (MRI);

机译：细胞疗法;血管疾病;磁共振成像（MRI）;

相似文献

外文文献
中文文献
专利

1. Administration of ALDH Bright Cells to Patients With Intermittent Claudication: The NHLBI CCTRN PACE Trial [J] . Perin Emerson C., Murphy Michael, March Keith, Circulation: An Official Journal of the American Heart Association . 2016,第25期

机译：间歇性lau行患者使用ALDH亮细胞：NHLBI CCTRN PACE试验
2. Reproducibility of cuff-induced hyperemic popliteal artery flow analysis using phase-contrast MRI: Patients With Intermittent Claudication Injected With ALDH Bright Cells (PACE) trial [J] . Tomoki Fujii, Chikara Noda, Victor Nauffal, Journal of cardiovascular magnetic resonance : . 2016,第S1期

机译：使用相衬MRI进行套囊诱导的充血pop动脉血流分析的重现性：间歇性lau行患者注射ALDH Bright Cells（PACE）试验
3. Rationale and Design for PACE: Patients with Intermittent Claudication Injected with ALDH Bright Cells [J] . Perin Emerson C., Murphy Michael, Cooke John P., The American heart journal . 2014,第5期

机译：PACE的原理和设计：间歇性lau行患者注射ALDH亮细胞
4. Adhesion of Late Outgrowth Peripheral Blood Endothelial Progenitor Cells from Coronary Artery Disease Patients to Human Aortic Smooth Muscle Cells [C] . Cristina E. Fernandez, Lisa L. Satterwhite, Izundu Obi-Onuoha, Society for Biomaterials fall symposium 2012.;vol. 34. . 2012

机译：冠状动脉疾病患者晚期末梢外周血内皮祖细胞对人主动脉平滑肌细胞的粘附
5. Reproducibility of cuff-induced hyperemic popliteal artery flow analysis using phase-contrast MRI: Patients With Intermittent Claudication Injected With ALDH Bright Cells (PACE) trial [O] . Tomoki Fujii, Chikara Noda, Victor Nauffal, 2016

机译：使用相衬MRI进行套囊诱导的充血pop动脉血流分析的重现性：间歇性lau行患者注射ALDH Bright Cells（PACE）试验
6. Reproducibility of cuff-induced hyperemic popliteal artery flow analysis using phase-contrast MRI: Patients With Intermittent Claudication Injected With ALDH Bright Cells (PACE) trial [O] . Tomoki Fujii, Chikara Noda, Victor Nauffal, 2016

机译：使用相衬MRI进行套囊诱导的充血pop动脉血流分析的重现性：注射ALDH Bright Cells（PACE）的间歇性C行患者

Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN Patients with Intermittent Claudication Injected with ALDH Bright Cells (PACE) Trial

摘要

著录项

相似文献

相关主题

期刊订阅