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首页> 美国卫生研究院文献>other >Quantification of Coupled Stiffness and Fiber Orientation Remodeling in Hypertensive Rat Right-Ventricular Myocardium Using 3D Ultrasound Speckle Tracking with Biaxial Testing
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Quantification of Coupled Stiffness and Fiber Orientation Remodeling in Hypertensive Rat Right-Ventricular Myocardium Using 3D Ultrasound Speckle Tracking with Biaxial Testing

机译：使用双轴测试的3D超声斑点跟踪对高血压大鼠右心室心肌的耦合刚度和纤维取向重塑进行定量

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Mechanical and structural changes of right ventricular (RV) in response to pulmonary hypertension (PH) are inadequately understood. While current standard biaxial testing provides information on the mechanical behavior of RV tissues using surface markers, it is unable to fully assess structural and mechanical properties across the full tissue thickness. In this study, the mechanical and structural properties of normotensive and pulmonary hypertension right ventricular (PHRV) myocardium through its full thickness were examined using mechanical testing combined with 3D ultrasound speckle tracking (3D-UST). RV pressure overload was induced in Sprague–Dawley rats by pulmonary artery (PA) banding. The second Piola–Kirchhoff stress tensors and Green-Lagrangian strain tensors were computed in the RV myocardium using the biaxial testing combined with 3D-UST. A previously established non-linear curve-fitting algorithm was applied to fit experimental data to a Strain Energy Function (SEF) for computation of myofiber orientation. The fiber orientations obtained by the biaxial testing with 3D-UST compared well with the fiber orientations computed from the histology. In addition, the re-orientation of myofiber in the right ventricular free wall (RVFW) along longitudinal direction (apex-to-outflow-tract direction) was noticeable in response to PH. For normotensive RVFW samples, the average fiber orientation angles obtained by 3D-UST with biaxial test spiraled from 20° at the endo-cardium to -42° at the epi-cardium (Δ = 62°). For PHRV samples, the average fiber orientation angles obtained by 3D-UST with biaxial test had much less spiral across tissue thickness: 3° at endo-cardium to -7° at epi-cardium (Δ = 10°, P<0.005 compared to normotensive).
机译：对于肺动脉高压（PH）的右心室（RV）的机械和结构变化了解不足。尽管当前的标准双轴测试使用表面标志物提供了有关RV组织力学行为的信息，但它无法完全评估整个组织厚度上的结构和力学特性。在这项研究中，使用机械测试结合3D超声散斑跟踪（3D-UST）来检查正常血压和肺动脉高压右心室（PHRV）心肌的力学和结构特性。 Sprague-Dawley大鼠通过肺动脉（PA）束带诱发RV压力超负荷。使用双轴测试结合3D-UST在RV心肌中计算了第二个Piola–Kirchhoff应力张量和Green-Lagrangian应变张量。应用先前建立的非线性曲线拟合算法将实验数据拟合到应变能函数（SEF），以计算肌纤维取向。通过3D-UST双轴测试获得的纤维取向与根据组织学计算得出的纤维取向进行了很好的比较。另外，响应于PH，肌纤维在右心室自由壁（RVFW）中沿纵向（顶点到流出通道的方向）的重新定向也很明显。对于正常血压的RVFW样品，通过3D-UST进行双轴测试获得的平均纤维取向角从心内膜的20°螺旋到心外膜的-42°（Δ= 62°）。对于PHRV样品，通过3D-UST进行双轴测试获得的平均纤维取向角在整个组织厚度上的螺旋要小得多：心内膜为3°，外膜心为-7°（Δ= 10°，P <0.005血压正常）。

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