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Endogenous Retroviruses in Fish Genomes: From Relics of Past Infections to Evolutionary Innovations?

机译:鱼类基因组中的内源性逆转录病毒:从过去感染的遗迹到进化创新?

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摘要

The increasing availability of fish genome sequences has allowed to gain new insights into the diversity and host distribution of retroviruses in fish and other vertebrates. This distribution can be assessed through the identification and analysis of endogenous retroviruses, which are proviral remnants of past infections integrated in genomes. Retroviral sequences are probably important for evolution through their ability to induce rearrangements and to contribute regulatory and coding sequences; they may also protect their host against new infections. We argue that the current mass of genome sequences will soon strongly improve our understanding of retrovirus diversity and evolution in aquatic animals, with the identification of new/re-emerging elements and host resistance genes that restrict their infectivity.
机译:鱼基因组序列的可用性不断提高,使人们对鱼和其他脊椎动物中逆转录病毒的多样性和宿主分布有了新的认识。可以通过鉴定和分析内源性逆转录病毒来评估这种分布,内源性逆转录病毒是整合到基因组中的过去感染的前病毒残留物。逆转录病毒序列通过其诱导重排以及贡献调控序列和编码序列的能力可能对进化很重要。他们还可以保护宿主免受新的感染。我们认为,当前的基因组序列质量将很快增强我们对水生动物逆转录病毒多样性和进化的了解,并鉴定出会限制其传染性的新的/再现元件和宿主抗性基因。

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