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Inverse Correlation between Heart Rate Variability and Heart Rate Demonstrated by Linear and Nonlinear Analysis

机译:线性和非线性分析表明心率变异性与心率之间的反相关

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摘要

The dynamical fluctuations in the rhythms of biological systems provide valuable information about the underlying functioning of these systems. During the past few decades analysis of cardiac function based on the heart rate variability (HRV; variation in R wave to R wave intervals) has attracted great attention, resulting in more than 17000-publications (PubMed list). However, it is still controversial about the underling mechanisms of HRV. In this study, we performed both linear (time domain and frequency domain) and nonlinear analysis of HRV data acquired from humans and animals to identify the relationship between HRV and heart rate (HR). The HRV data consists of the following groups: (a) human normal sinus rhythm (n = 72); (b) human congestive heart failure (n = 44); (c) rabbit sinoatrial node cells (SANC; n = 67); (d) conscious rat (n = 11). In both human and animal data at variant pathological conditions, both linear and nonlinear analysis techniques showed an inverse correlation between HRV and HR, supporting the concept that HRV is dependent on HR, and therefore, HRV cannot be used in an ordinary manner to analyse autonomic nerve activity of a heart.
机译:生物系统节律的动态波动为这些系统的潜在功能提供了有价值的信息。在过去的几十年中,基于心率变异性(HRV; R波到R波间隔的变化)对心功能的分析引起了极大的关注,发表了17000多个出版物(PubMed列表)。但是,关于HRV的潜在机制仍存在争议。在这项研究中,我们对从人和动物获得的HRV数据进行了线性(时域和频域)和非线性分析,以确定HRV和心率(HR)之间的关系。 HRV数据包括以下几类:(a)人类正常窦性心律(n = 72); (b)人类充血性心力衰竭(n = 44); (c)兔窦房结细胞(SANC; n = 67); (d)清醒大鼠(n = 11)。在各种病理条件下的人和动物数据中,线性和非线性分析技术均显示HRV和HR之间呈反相关关系,支持HRV依赖于HR的概念,因此,HRV无法以常规方式用于分析自主神经心脏的神经活动。

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