• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Gray Matter Abnormalities in Temporal Lobe Epilepsy: Relationships with Resting-State Functional Connectivity and Episodic Memory Performance
【2h】

Gray Matter Abnormalities in Temporal Lobe Epilepsy: Relationships with Resting-State Functional Connectivity and Episodic Memory Performance

机译：颞叶癫痫的灰色物质异常：与静息状态功能连接性和情景记忆性能的关系

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Temporal lobe epilepsy (TLE) affects multiple brain regions through evidence from both structural (gray matter; GM) and functional connectivity (FC) studies. We tested whether these structural abnormalities were associated with FC abnormalities, and assessed the ability of these measures to explain episodic memory impairments in this population. A resting-state and T1 sequences were acquired on 94 (45 with mesial temporal pathology) TLE patients and 50 controls, using magnetic resonance imaging (MRI) technique. A voxel-based morphometry analysis was computed to determine the GM volume differences between groups (right, left TLE, controls). Resting-state FC between the abnormal GM volume regions was computed, and compared between groups. Finally, we investigated the relation between EM, GM and FC findings. Patients with and without temporal pathology were analyzed separately. The results revealed reduced GM volume in multiple regions in the patients relative to the controls. Using FC, we found the abnormal GM regions did not display abnormal functional connectivity. Lastly, we found in left TLE patients, verbal episodic memory was associated with abnormal left posterior hippocampus volume, while in right TLE, non-verbal episodic memory was better predicted by resting-state FC measures. This study investigated TLE abnormalities using a multi-modal approach combining GM, FC and neurocognitive measures. We did not find that the GM abnormalities were functionally or abnormally connected during an inter-ictal resting state, which may reflect a weak sensitivity of functional connectivity to the epileptic network. We provided evidence that verbal and non-verbal episodic memory in left and right TLE patients may have distinct relationships with structural and functional measures. Lastly, we provide data suggesting that in the setting of occult, non-lesional right TLE pathology, a coupling of structural and functional abnormalities in extra-temporalon-ictal regions is necessary to produce reductions in episodic memory recall. The latter, in particular, demonstrates the complex structure/function interactions at work when trying to understand cognition in TLE, suggesting that subtle network effects can emerge bearing specific relationships to hemisphere and the type of pathology.
机译：颞叶癫痫（TLE）通过结构性研究（灰质； GM）和功能连接性（FC）研究的证据影响多个大脑区域。我们测试了这些结构异常是否与FC异常有关，并评估了这些措施解释该人群中情节性记忆障碍的能力。使用磁共振成像（MRI）技术在94位（45位患有颞叶颞叶病理）的TLE患者和50位对照中获得了静息状态和T1序列。计算基于体素的形态分析，以确定各组（右，左TLE，对照）之间的GM体积差异。计算异常GM体积区域之间的静止状态FC，并在组之间进行比较。最后，我们调查了EM，GM和FC结果之间的关系。有和没有颞病理的患者分别进行分析。结果显示相对于对照，患者多个区域的GM体积降低。使用FC，我们发现异常的GM区域没有显示异常的功能连接。最后，我们发现在左TLE患者中，口头情景记忆与左后海马区容积异常有关，而在右TLE中，通过静息状态FC措施可以更好地预测非语言性情景记忆。这项研究使用结合了GM，FC和神经认知措施的多模式方法研究了TLE异常。我们没有发现在发作间隔期间，GM异常在功能上或异常连接，这可能反映了功能连接对癫痫网络的敏感性较弱。我们提供的证据表明，左TLE和右TLE患者的口头和非口头情节记忆可能与结构和功能指标有明显的关系。最后，我们提供的数据表明，在隐匿性，非病变性右TLE病理学背景下，时空/非关键区域中结构和功能异常的耦合对于减少情景记忆的回忆是必要的。当试图理解TLE中的认知时，后者尤其证明了工作中复杂的结构/功能相互作用，这表明可能出现微妙的网络效应，与半球和病理类型之间存在特定的关系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号