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首页> 美国卫生研究院文献>other >Lactobacillus rhamnosus GG Intake Modifies Preschool Children’s Intestinal Microbiota Alleviates Penicillin-Associated Changes and Reduces Antibiotic Use
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Lactobacillus rhamnosus GG Intake Modifies Preschool Children’s Intestinal Microbiota Alleviates Penicillin-Associated Changes and Reduces Antibiotic Use

机译：鼠李糖乳杆菌GG的摄入量可改善学龄前儿童的肠道菌群减轻与青霉素有关的变化并减少抗生素的使用

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Antibiotic use is considered among the most severe causes of disturbance to children’s developing intestinal microbiota, and frequently causes adverse gastrointestinal effects ranging from mild and transient diarrhoea to life-threatening infections. Probiotics are commonly advocated to help in preventing antibiotic-associated gastrointestinal symptoms. However, it is currently unknown whether probiotics alleviate the antibiotic-associated changes in children’s microbiota. Furthermore, it is not known how long-term probiotic consumption influences the developing microbiota of children. We analysed the influence of long-term Lactobacillus rhamnosus GG intake on preschool children’s antibiotic use, and antibiotic-associated gastrointestinal complaints in a double blind, randomized placebo-controlled trial with 231 children aged 2–7. In addition, we analysed the effect of L. rhanmosus GG on the intestinal microbiota in a subset of 88 children. The results show that long-term L. rhamnosus GG supplementation has an influence on the composition of the intestinal microbiota in children, causing an increase in the abundance of Prevotella, Lactococcus, and Ruminococcus, and a decrease in Escherichia. The treatment appeared to prevent some of the changes in the microbiota associated with penicillin use, but not those associated with macrolide use. The treatment, however, did reduce the frequency of gastrointestinal complaints after a macrolide course. Finally, the treatment appeared to prevent certain bacterial infections for up to 3 years after the trial, as indicated by reduced antibiotic use.>Trial Registration: ClinicalTrials.gov
机译：抗生素的使用被认为是儿童发育中的肠道菌群紊乱的最严重原因之一，并经常引起胃肠道不良反应，从轻度和暂时性腹泻到威胁生命的感染。通常提倡益生菌以帮助预防与抗生素有关的胃肠道症状。但是，目前尚不清楚益生菌是否能缓解儿童微生物群中与抗生素相关的变化。此外，还不清楚长期服用益生菌如何影响儿童发育中的微生物群。在一项针对231名2至7岁儿童的随机双盲随机对照试验中，我们分析了长期摄入鼠李糖乳杆菌GG对学龄前儿童使用抗生素以及与抗生素相关的胃肠道不适的影响。此外，我们分析了鼠李糖GG对88名儿童亚组中肠道菌群的影响。结果表明，长期补充鼠李糖乳杆菌GG对儿童肠道菌群的组成有影响，导致普氏菌，乳球菌和鲁米诺球菌的丰度增加，而大肠埃希氏菌减少。该治疗似乎可以防止与青霉素使用相关的微生物群的某些变化，但不能阻止与大环内酯使用相关的那些变化。然而，这种治疗确实降低了大环内酯类药物治疗后胃肠道不适的发生频率。最终，这种治疗似乎可以在试验后长达3年的时间内预防某些细菌感染，这可以通过减少抗生素的使用来表明。>试验注册：ClinicalTrials.gov

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