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首页> 美国卫生研究院文献>other >Von Willebrand factor is reversibly decreased during torpor in 13-lined ground squirrels
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Von Willebrand factor is reversibly decreased during torpor in 13-lined ground squirrels

机译：冯·威兰布兰德因子在13排地面松鼠的比赛中可逆地降低

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During torpor in a hibernating mammal, decreased blood flow increases the risk of blood clots such as deep vein thrombi (DVT). In other animal models platelets, neutrophils, monocytes and von Willebrand factor (VWF) have been found in DVT. Previous research has shown that hibernating mammals decrease their levels of platelets and clotting factors VIII (FVIII) and IX (FIX), increasing both bleeding time and activated partial throm-boplastin time. In this study, FVIII, FIX and VWF activities and mRNA levels were measured in torpid and non-hibernating ground squirrels (Ictidomys tridecemlineatus). Here, we show that VWF high molecular weight multimers, collagen-binding activity, lung mRNA and promoter activity decrease during torpor. The VWF multimers reappear in plasma within 2 h of arousal in the spring. Similarly, FIX activity and liver mRNA both dropped threefold during torpor. In contrast, FVIII liver mRNA levels increased twofold while its activity dropped threefold, consistent with a post-transcriptional decrease in FVIII stability in the plasma due to decreased VWF levels. Finally, both neutrophils and monocytes are decreased eightfold during torpor which could slow the formation of DVT. In addition to providing insight in how blood clotting can be regulated to allow mammals to survive in extreme environments, hibernating ground squirrels provide an interesting model for studying.
机译：在冬眠的哺乳动物中进行躯干时，血流量减少会增加发生诸如深静脉血栓（DVT）等血凝块的风险。在其他动物模型中，已在DVT中发现了血小板，嗜中性粒细胞，单核细胞和von Willebrand因子（VWF）。先前的研究表明，冬眠的哺乳动物会降低其血小板和凝血因子VIII（FVIII）和IX（FIX）的水平，从而增加出血时间和活化的部分凝血酶-增塑酶时间。在这项研究中，测量了八角和非冬眠地松鼠（Ictidomys tridecemlineatus）的FVIII，FIX和VWF活性以及mRNA水平。在这里，我们显示VWF高分子量多聚体，胶原蛋白结合活性，肺mRNA和启动子活性降低。在春季唤醒后2小时内，VWF多聚体重新出现在血浆中。相似地，在activity割期间，FIX活性和肝mRNA均下降了三倍。相反，FVIII肝mRNA的水平增加了两倍，而其活性却下降了三倍，这与由于VWF水平降低导致血浆中FVIII稳定性的转录后降低有关。最终，中性粒细胞和单核细胞在干裂过程中都减少了八倍，这可能减慢了DVT的形成。冬眠的松鼠除了提供关于如何调节血液凝结以使哺乳动物在极端环境中生存的见识之外，冬眠的松鼠还提供了一个有趣的研究模型。

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