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The relationship between adherence to clinic appointments and year-one mortality for newly enrolled HIV infected patients at a regional referral hospital in Western Kenya January 2011–December 2012

机译:2011年1月至2012年12月在肯尼亚西部的区域转诊医院接受新诊治的HIV感染患者的门诊任命与一年死亡率之间的关系

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摘要

This retrospective cohort analysis was conducted to describe the association between adherence to clinic appointments and mortality, one year after enrollment into HIV care. We examined appointment-adherence for newly enrolled patients between January 2011 and December 2012 at a regional referral hospital in western Kenya. The outcomes of interest were patient default, risk factors for repeat default, and year-one risk of death. Of 582 enrolled patients, 258 (44%) were defaulters. GEE revealed that once having been defaulters, patients were significantly more likely to repeatedly default (OR 1.4; 95% CI 1.12–1.77), especially the unemployed (OR 1.43; 95% CI 1.07–1.91), smokers (OR 2.22; 95% CI 1.31–3.76), and those with no known disclosure (OR 2.17; 95% CI 1.42–3.3). Nineteen patients (3%) died during the follow-up period. Cox proportional hazards revealed that the risk of death was significantly higher among defaulters (HR 3.12; 95% CI 1.2–8.0) and increased proportionally to the rate of patient defau HR was 4.05 (95% CI1.38–11.81) and 4.98 (95% CI 1.45–17.09) for a cumulative of 4–60 and ≥60 days elapsed between all scheduled and actual clinic appointment dates, respectively. Risk factors for repeat default suggest a need to deliver targeted adherence programs.
机译:进行这项回顾性队列分析,以描述在加入HIV护理一年后,遵守诊所任命与死亡率之间的关系。我们检查了2011年1月至2012年12月之间在肯尼亚西部的一家地区转诊医院接受新招募的患者的约会依从性。感兴趣的结果是患者违约,重复违约的风险因素以及一年死亡风险。在582名登记患者中,有258名(44%)是违约者。 GEE揭示,一旦成为违法者,患者重复吸烟的可能性更高(OR 1.4; 95%CI 1.12–1.77),尤其是失业者(OR 1.43; 95%CI 1.07–1.91),吸烟者(OR 2.22; 95% CI 1.31-3.76),以及未披露的信息(OR 2.17; 95%CI 1.42-3.3)。随访期间死亡19例(3%)。考克斯比例风险表明,违约者的死亡风险显着更高(HR 3.12; 95%CI 1.2–8.0),并且与患者违约率成正比;在所有计划的和实际的诊所预约日期之间,HR分别为4.05(95%CI1.38-11.81)和4.98(95%CI 1.45-17.09),累计时间分别为4-60天和≥60天。重复违约的风险因素表明需要提供有针对性的遵守计划。

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