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首页> 美国卫生研究院文献>The Journal of Experimental Medicine >BIPHASIC PATTERN OF THYMUS REGENERATION AFTER WHOLE-BODY IRRADIATION
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BIPHASIC PATTERN OF THYMUS REGENERATION AFTER WHOLE-BODY IRRADIATION

机译：全身照射后胸腺再生的双生型

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Whole-body irradiation of mice with 300 or 400 R causes a precipitous fall in thymus weight, followed by an increase in the mitotic index and an almost complete restoration of thymus mass. This phase is followed by a secondary fall in thymus weight and gradual recovery. This secondary fall can be prevented by intravenous injection of bone marrow or shielding of the hind limbs during irradiation. The hypothesis is proposed that the thymus depends on the migration of cells from the bone marrow to the thymus for the maintenance of its cell population. Bone marrow cells with chromosome markers injected intravenously into normal or lightly irradiated (150 R) animals do not populate the host bone marrow to any significant degree. After whole-body irradiation with heavy doses (400 R), donor cells dominate the marrow. There may be a competition between dividing cells in the bone marrow which regulates proliferation of hemic cells. Bone marrow cells with marker chromosomes do not repopulate the thymus in irradiated animals until long after repopulating the bone marrow. It is possible that these cells have to pass through the marrow or the blood-marrow barrier to acquire characteristics needed for entering the thymus. After whole-body irradiation with 500 R or more, the first phase of regeneration of the thymus, represented by an increase in the mitotic index, does not occur to a significant degree. Apparently cells in the thymus capable of proliferation have been largely eliminated, and restoration of organ mass depends chiefly on seeding from other sources, probably the bone marrow. After whole-body irradiation with 200 R, only the first phase of thymus weight loss and regeneration takes place. Probably bone marrow injury is too small to interfere with the supply of cells repopulating the thymus.
机译：用300或400 R对小鼠进行全身照射会导致胸腺重量急剧下降，然后导致有丝分裂指数增加，胸腺质量几乎完全恢复。此阶段之后，胸腺重量继发下降并逐渐恢复。可以通过在静脉内注射骨髓或屏蔽后肢来预防继发性跌倒。提出了这样的假设：胸腺依赖于细胞从骨髓向胸腺的迁移来维持其细胞群。静脉内将具有染色体标记的骨髓细胞注射到正常或轻度辐射（150 R）的动物中，不会显着程度地填充宿主骨髓。大剂量（400 R）全身照射后，供体细胞占主导地位。骨髓中的分裂细胞之间可能存在竞争，从而调节血细胞的增殖。具有标记染色体的骨髓细胞直到重新填充骨髓后很长时间才在受辐照的动物中重新分布胸腺。这些细胞可能必须穿过骨髓或骨髓屏障才能获得进入胸腺所需的特征。用500 R或更高的剂量进行全身照射后，以有丝分裂指数增加为代表的胸腺再生的第一阶段不会显着地发生。显然，胸腺中能够增殖的细胞已被基本消除，器官质量的恢复主要取决于其他来源的种子，可能是骨髓。用200 R全身照射后，仅发生胸腺重量减轻和再生的第一阶段。骨髓损伤可能太小，以至于无法干扰胸腺再生细胞的供应。

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