• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular immunology >The importance of infiltrating neutrophils in SDF-1 production leading to regeneration of the thymus after whole-body X-irradiation.
【24h】

The importance of infiltrating neutrophils in SDF-1 production leading to regeneration of the thymus after whole-body X-irradiation.

机译：渗透中性粒细胞在SDF-1产生中的重要性，导致全身X射线照射后胸腺再生。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Our previous study demonstrated that neutrophils transiently infiltrated into a site where apoptosis had been induced. However, the role of infiltrating neutrophils has not been fully elucidated. In this study, we examined their role in regeneration of the thymus after whole-body X-irradiation by focusing on SDF-1 production. After X-irradiation, the thymus became severely atrophied presumably due to phagocytosis of apoptotic thymocytes. At that time, a significant number of neutrophils were detected in the thymus. The thymus was then partially regenerated on day 7, whereas the level of SDF-1 in it was significantly increased on days 3 and 5. Depletion of neutrophils greatly impaired SDF-1 production and the thymus regeneration. Moreover, administration of a CXCR4 antagonist also greatly suppressed the thymus regeneration. Furthermore, coculturing of a stromal cell line with infiltrating neutrophils increased SDF-1 production. These results suggest that infiltrating neutrophils play an auxiliary role in regeneration of the thymus after whole-body X-irradiation through augmentation of SDF-1 production.
机译：我们以前的研究表明，中性粒细胞瞬时渗透到诱导凋亡的部位。但是，尚未完全阐明浸润性中性粒细胞的作用。在这项研究中，我们重点研究了SDF-1的产生，研究了它们在全身X射线照射后在胸腺再生中的作用。 X射线照射后，可能是由于凋亡性胸腺细胞的吞噬作用导致胸腺严重萎缩。当时，在胸腺中发现了大量嗜中性粒细胞。然后，在第7天，部分胸腺再生，而在第3天和第5天，胸腺中SDF-1的水平显着增加。中性粒细胞的消耗极大地损害了SDF-1的产生和胸腺的再生。此外，施用CXCR4拮抗剂也极大地抑制了胸腺的再生。此外，将基质细胞系与浸润的中性粒细胞共培养可增加SDF-1的产生。这些结果表明，浸润的中性粒细胞通过增加SDF-1的产生，在全身X射线照射后在胸腺再生中起辅助作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号