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首页> 外文期刊>International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations >Alteration of lipid composition of rat thymus during thymic atrophy by whole-body X-irradiation.
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Alteration of lipid composition of rat thymus during thymic atrophy by whole-body X-irradiation.

机译：全身X射线照射在胸腺萎缩过程中大鼠胸腺脂质组成的变化。

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PURPOSE: Thymic atrophy induced by irradiation is well known, but in vivo lipid metabolism during the atrophy has not been studied in detail. We determined the lipid composition of rat thymus during the progress of thymic atrophy induced by whole-body X-irradiation. MATERIALS AND METHODS: The lipid analysis of total lipid of rat thymus after 5 Gy whole-body X-irradiation was performed by high performance liquid chromatography and gas chromatography equipped with mass spectrometry. RESULTS: Major changes observed were a 16.2-fold elevation of cholesterol ester (CE) during a 48-h post-irradiation period and a 6.1-fold increase of alkyldiacylglycerol (ADG) at 24 h. Other significant changes detected were an increase in lysophosphatidylcholine and a transient increase in ceramide and phosphatidic acid. Acyl chain analysis revealed a substantial elevation of arachidonate composition of CE and an unusually high content of polyunsaturated fatty acids (71.5%, mol/mol) in ADG. CONCLUSION: Lipid analysis shows that the thymic atrophy by X-irradiation was accompanied by a significant change in thymic lipids. This in vivo result opens up new vistas of the role of lipids in apoptosis and phagocytosis during thymic atrophy.
机译：目的：辐射引起的胸腺萎缩是众所周知的，但是尚未详细研究萎缩过程中的体内脂质代谢。我们确定了在全身X射线诱导的胸腺萎缩过程中大鼠胸腺的脂质组成。材料与方法：采用高效液相色谱仪和配备质谱仪的气相色谱仪对5 Gy全身X射线照射后的大鼠胸腺总脂质进行了脂质分析。结果：观察到的主要变化是在辐照后48小时内胆固醇酯（CE）升高16.2倍，在24 h烷基二酰基甘油（ADG）升高6.1倍。检测到的其他显着变化是溶血磷脂酰胆碱的增加以及神经酰胺和磷脂酸的短暂增加。酰基链分析显示，CE的花生四烯酸酯成分显着提高，ADG中多不饱和脂肪酸的含量异常高（71.5％，mol / mol）。结论：脂质分析表明，X射线照射引起的胸腺萎缩伴随着胸腺脂质的显着变化。该体内结果开启了胸腺萎缩过程中脂质在细胞凋亡和吞噬作用中作用的新视野。

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