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Neural tissue motion impacts cerebrospinal fluid dynamics at the cervical medullary junction: a patient-specific moving-boundary computational model

机译：神经组织运动影响颈髓交界处的脑脊髓液动力学：特定于患者的移动边界计算模型

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Central nervous system (CNS) tissue motion of the brain occurs over 30 million cardiac cycles per year due to intracranial pressure differences caused by the pulsatile intracranial blood flow and cerebrospinal fluid (CSF) motion within the intracranial space. This motion has been found to be elevated in type 1 Chiari malformation. The impact of CNS tissue motion on CSF dynamics was assessed using moving-boundary computational fluid dynamics (CFD) models of the cervical-medullary junction (CMJ). The cerebellar tonsils and spinal cord were modeled as rigid surfaces moving in the caudocranial direction over the cardiac cycle. The CFD boundary conditions were based on in vivo MR imaging of a 35-year old female Chiari malformation patient with ~150 to 300 μm motion of the cerebellar tonsils and spinal cord, respectively. Results showed that tissue motion increased CSF pressure dissociation across the CMJ and peak velocities up to 120% and 60%, respectively. Alterations in CSF dynamics were most pronounced near the CMJ and during peak tonsillar velocity. These results show a small CNS tissue motion at the CMJ can alter CSF dynamics for a portion of the cardiac cycle and demonstrate the utility of CFD modeling coupled with MR imaging to help understand CSF dynamics.
机译：由于颅内压差是由于颅内空间搏动性颅内血流和脑脊液（CSF）运动引起的颅内压差，因此大脑的中枢神经系统（CNS）组织运动每年发生超过3000万个心动周期。已经发现该运动在1型Chiari畸形中升高。中枢神经系统组织运动对脑脊液动力学的影响使用颈髓交界处（CMJ）的移动边界计算流体动力学（CFD）模型进行评估。小脑扁桃体和脊髓被建模为在整个心动周期中沿朝颅方向移动的刚性表面。 CFD边界条件基于一名35岁女性Chiari畸形患者的体内MR成像，其小脑扁桃体和脊髓运动分别约为150至300μm。结果表明，组织运动增加了跨CMJ的CSF压力解离，峰值速度分别高达120％和60％。脑脊液动力学的变化在CMJ附近和扁桃体峰值速度期间最为明显。这些结果表明，CMJ处的少量CNS组织运动可以改变一部分心动周期的CSF动态，并证明CFD建模与MR成像结合使用有助于了解CSF动态。

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