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首页> 美国卫生研究院文献>other >Gulf War Agent Exposure Causes Impairment of Long-Term Memory Formation and Neuropathological Changes in a Mouse Model of Gulf War Illness
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Gulf War Agent Exposure Causes Impairment of Long-Term Memory Formation and Neuropathological Changes in a Mouse Model of Gulf War Illness

机译：海湾战争特工的暴露导致长期记忆形成和海湾战争疾病的小鼠模型中的神经病理变化的损害。

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摘要

Gulf War Illness (GWI) is a chronic multisymptom illness with a central nervous system component such as memory deficits, neurological, and musculoskeletal problems. There are ample data that demonstrate that exposure to Gulf War (GW) agents, such as pyridostigmine bromide (PB) and pesticides such as permethrin (PER), were key contributors to the etiology of GWI post deployment to the Persian GW. In the current study, we examined the consequences of acute (10 days) exposure to PB and PER in C57BL6 mice. Learning and memory tests were performed at 18 days and at 5 months post-exposure. We investigated the relationship between the cognitive phenotype and neuropathological changes at short and long-term time points post-exposure. No cognitive deficits were observed at the short-term time point, and only minor neuropathological changes were detected. However, cognitive deficits emerged at the later time point and were associated with increased astrogliosis and reduction of synaptophysin staining in the hippocampi and cerebral cortices of exposed mice, 5 months post exposure. In summary, our findings in this mouse model of GW agent exposure are consistent with some GWI symptom manifestations, including delayed onset of symptoms and CNS disturbances observed in GWI veterans.
机译：海湾战争疾病（GWI）是一种慢性多症状疾病，具有中枢神经系统成分，例如记忆力不足，神经系统疾病和肌肉骨骼问题。有大量数据表明，暴露于海湾战争（GW）病原体，例如溴化斯的明溴（PB）和杀虫剂例如氯菊酯（PER），是波斯GW部署后GWI病因的关键因素。在当前的研究中，我们检查了C57BL6小鼠急性（10天）暴露于PB和PER的后果。暴露后18天和5个月进行学习和记忆测试。我们调查了暴露后短期和长期时间点的认知表型与神经病理变化之间的关系。在短期内未观察到认知缺陷，仅检测到较小的神经病理学改变。然而，在暴露后5个月，认知缺陷在较晚的时间点出现，并与星形胶质细胞增多症和暴露的小鼠海马和大脑皮质的突触素染色减少有关。总而言之，我们在该小鼠的GW剂暴露模型中的发现与某些GWI症状表现是一致的，包括在GWI退伍军人中观察到的症状延迟发作和中枢神经系统紊乱。

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