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Effect of the novel positive allosteric modulator of mGluR2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model

机译：新型mGluR2 AZD8529的正构构构调节剂对长时间禁欲大鼠模型中甲基苯丙胺渴望的影响

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BackgroundCue-induced methamphetamine craving increases after prolonged forced (experimenter-imposed) abstinence from the drug (incubation of methamphetamine craving). Here, we determined whether this incubation phenomenon would occur under conditions that promote voluntary (self-imposed) abstinence. We also determined the effect of the novel mGluR2 positive allosteric modulator, AZD8529, on incubation of methamphetamine craving after forced or voluntary abstinence.

机译：背景长期强迫戒酒（实验者施加）戒酒后（甲基苯丙胺渴望培养），提示导致的甲基苯丙胺渴望增加。在这里，我们确定了这种孵化现象是否会在促进自愿（自我施加）禁欲的条件下发生。我们还确定了新型mGluR2阳性变构调节剂AZD8529在强迫或自愿戒断后对甲基苯丙胺渴望的温育中的作用。

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期刊名称 other
作者
Daniele Caprioli; Marco Venniro; Tamara Zeric; Xuan Li; Sweta Adhikary; Rajtarun Madangopal; Nathan J. Marchant; Federica Lucantonio; Geoffrey Schoenbaum; Jennifer M. Bossert; Yavin Shaham;
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年(卷),期 -1(78),7
年度 -1
页码 463–473
总页数 20
原文格式 PDF
正文语种
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关键词
psychostimulants palatable food discrete choice self-administration extended access incubation of drug craving abstinence relapse addiction models mGluR2/3 positive allosteric modulator glutamate;

机译：精神兴奋剂;可口的食物;选择不当;自我管理;扩大使用范围;对药物的渴望;禁欲;复发;成瘾模型;mGluR2 / 3;正构构调节剂;谷氨酸;

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专利

1. Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model [J] . Caprioli Daniele, Venniro Marco, Zeric Tamara, Biological psychiatry . 2015,第7期

机译：新型代谢型谷氨酸受体2 AZD8529的正变构调节剂对长时间自愿戒断后对甲基苯丙胺渴望的潜伏期的影响
2. AZD8529, a positive allosteric modulator at the mGluR2 receptor, does not improve symptoms in schizophrenia: A proof of principle study [J] . Litman Robert E., Smith Mark A., Doherty James J., Schizophrenia research . 2016,第1a3期

机译：AZD8529是mGluR2受体的正变构调节剂，不能改善精神分裂症的症状：一项原理研究的证明
3. AZD8529, a positive allosteric modulator at the mGluR2 receptor, does not improve symptoms in schizophrenia: A proof of principle study [J] . Litman Robert E., Smith Mark A., Doherty James J., Schizophrenia research . 2016,第1a3期

机译：AZD8529是MGLUR2受体的阳性变构调节剂，不会改善精神分裂症的症状：原则研究证明
4. IDENTIFICATION OF NADPH-INDEPENDENT GSH CONJUGATES OF ACETYLENE-CONTAINING POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 5 [C] . Xiaoliang Zhuo, Xiaohua Huang, Andrew Degnan, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：鉴定含乙炔谷氨酸受体亚型5的含乙炔的阳性变构调节剂的NADPH-无关的GSH缀合物
5. Synaptic Adaptations Associated With Incubation of Methamphetamine Craving [D] . Murray, Conor H. 2019

机译：与甲基苯丙胺渴望孵育相关的突触适应
6. The mGluR2 Positive Allosteric Modulator AZD8529 and Cue-Induced Relapse to Alcohol Seeking in Rats [O] . Eric Augier, Russell S Dulman, Caroline Rauffenbart, 2016

机译：mGluR2阳性变构调节剂AZD8529和提示诱导的大鼠饮酒复发。
7. Effect of the novel positive allosteric modulator of metabotropic glutamate receptor 2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model [O] . Caprioli, Daniele, Venniro, Marco, Zeric, Tamara, 2015

机译：新型代谢型谷氨酸受体2 AZD8529的正变构调节剂对长时间自愿戒断大鼠模型中甲基苯丙胺的影响

Effect of the novel positive allosteric modulator of mGluR2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model

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