Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model

Caprioli Daniele; Venniro Marco; Zeric Tamara; Li Xuan; Adhikary Sweta; Madangopal Rajtarun; Marchant Nathan J.; Lucantonio Federica; Schoenbaum Geoffrey; Bossert Jennifer M.; Shaham Yavin

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Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model

机译：新型代谢型谷氨酸受体2 AZD8529的正变构调节剂对长时间自愿戒断后对甲基苯丙胺渴望的潜伏期的影响

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BACKGROUND: Cue-induced methamphetamine craving increases after prolonged forced (experimenter-imposed) abstinence from the drug (incubation of methamphetamine craving). Here, we determined whether this incubation phenomenon would occur under conditions that promote voluntary (self-imposed) abstinence. We also determined the effect of the novel metabotropic glutamate receptor 2 positive allosteric modulator, AZD8529, on incubation of methamphetamine craving after forced or voluntary abstinence.

机译：背景：长期强迫戒酒（由实验者强行禁欲）（冰毒的孵育）后，提示诱导的甲基苯丙胺渴望增加。在这里，我们确定了这种孵化现象是否会在促进自愿（自我施加）禁欲的条件下发生。我们还确定了新型代谢型谷氨酸受体2阳性变构调节剂AZD8529对强迫或自愿戒断后对甲基苯丙胺渴望的潜伏期的影响。

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《Biological psychiatry》 |2015年第7期|共11页
作者
Caprioli Daniele; Venniro Marco; Zeric Tamara; Li Xuan; Adhikary Sweta; Madangopal Rajtarun; Marchant Nathan J.; Lucantonio Federica; Schoenbaum Geoffrey; Bossert Jennifer M.; Shaham Yavin;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Abstinence; Addiction models; Discrete choice; Extended access; Glutamate; Incubation of drug craving; mGluR2/3; Palatable food; Positive allosteric modulator; Psychostimulants; Relapse; Self-administration;

机译：禁欲;成瘾模型;离散选择;扩展访问;谷氨酸;药物渴望的培养;mGluR2 / 3;可口的食物;正性变构调节剂;精神兴奋剂;复发;自我给药;

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1. Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model [J] . Caprioli Daniele, Venniro Marco, Zeric Tamara, Biological psychiatry . 2015,第7期

机译：新型代谢型谷氨酸受体2 AZD8529的正变构调节剂对长时间自愿戒断后对甲基苯丙胺渴望的潜伏期的影响
2. A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models [J] . Gene G.Kinney, Julie A.OBrien, Wei Lemaire, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2005,第1期

机译：代谢型谷氨酸受体亚型5的新型选择性正变构调节剂在大鼠行为模型中具有体内活性和抗精神病样作用
3. Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator [J] . WattersonL.R., KufahlP.R., NemirovskyN.E., Psychopharmacology . 2013,第1期

机译：代谢型谷氨酸受体5阴性变构调节剂fenobam对大鼠甲基苯丙胺，蔗糖和食物觅食行为的恢复作用减弱
4. IDENTIFICATION OF NADPH-INDEPENDENT GSH CONJUGATES OF ACETYLENE-CONTAINING POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 5 [C] . Xiaoliang Zhuo, Xiaohua Huang, Andrew Degnan, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：鉴定含乙炔谷氨酸受体亚型5的含乙炔的阳性变构调节剂的NADPH-无关的GSH缀合物
5. Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning in rodents. [D] . Fowler, Stephanie Wade. 2013

机译：代谢型谷氨酸受体5阳性变构调节剂CDPPB对啮齿类动物空间学习的影响。
6. Effect of the novel positive allosteric modulator of mGluR2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model [O] . Daniele Caprioli, Marco Venniro, Tamara Zeric, -1

机译：新型mGluR2 AZD8529的正构构构调节剂对长时间禁欲大鼠模型中甲基苯丙胺渴望的影响
7. Effect of the novel positive allosteric modulator of metabotropic glutamate receptor 2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model [O] . Caprioli, Daniele, Venniro, Marco, Zeric, Tamara, 2015

机译：新型代谢型谷氨酸受体2 AZD8529的正变构调节剂对长时间自愿戒断大鼠模型中甲基苯丙胺的影响

Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model

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