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首页> 美国卫生研究院文献>The Journal of Experimental Medicine >The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts
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The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts

机译：体内同种异体排斥反应的细胞基础。 I.首次移植心脏排斥反应的细胞要求

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摘要

The nature of the cells required for first-set graft rejection in vivo was examined by using an adoptive transfer system to restore heart- graft rejection in irradiated rats. Highly purified inocula of peripheral T lymphocytes were shown to quantitatively account for the restorative ability of adoptively transferred cells. These T cells were shown to be long-lived small lymphocytes which are not recently derived from the thymus during adult life. They belong to the pool of T cells which constantly recirculate from blood to lymph as shown by their rapid appearance in the lymph of iradiated syngeneic rats after intravenous injection. Neither B lymphocytes nor antibodies in the circulation or in the graft itself are required for first-set graft rejection.
机译：通过使用过继转移系统恢复受辐照大鼠的心脏移植排斥，检查了体内第一组移植排斥所需的细胞的性质。外周血T淋巴细胞的高纯度接种物可定量说明过继转移细胞的修复能力。这些T细胞被证明是长寿命的小淋巴细胞，它们在成年后并非最近来源于胸腺。它们属于T细胞库，这些T细胞在血液中不断循环至淋巴液，如静脉注射后在照射的同系大鼠的淋巴液中迅速出现所显示的那样。初次移植排斥反应不需要循环中或移植物中的B淋巴细胞或抗体。

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