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Innate Immune Pattern Recognition: A Cell Biological Perspective

机译:先天免疫模式识别:细胞生物学的角度。

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摘要

Receptors of the innate immune system detect conserved determinants of microbial and viral origin. Activation of these receptors initiates signaling events that culminate in an effective immune response. Recently, the view that innate immune signaling events rely on and operate within a complex cellular infrastructure has become an important framework for understanding the regulation of innate immunity. Compartmentalization within this infrastructure provides the cell with the ability to assign spatial information to microbial detection and regulate immune responses. Several cell biological processes play a role in the regulation of innate signaling responses; at the same time, innate signaling can engage cellular processes as a form of defense or to promote immunological memory. In this review, we highlight these aspects of cell biology in pattern-recognition receptor signaling by focusing on signals that originate from the cell surface, from endosomal compartments, and from within the cytosol.
机译:先天免疫系统的受体检测到微生物和病毒起源的保守决定簇。这些受体的激活引发信号传导事件,最终导致有效的免疫反应。最近,先天免疫信号事件依赖并在复杂的细胞基础设施中运行的观点已成为理解先天免疫调节的重要框架。在该基础设施中的分区化为细胞提供了将空间信息分配给微生物检测并调节免疫反应的能力。几种细胞生物学过程在先天信号应答的调节中起作用。同时,先天信号可以作为防御或促进免疫记忆的形式参与细胞过程。在这篇综述中,我们通过关注源于细胞表面,内体区室和细胞质内的信号,突出了模式识别受体信号传导中细胞生物学的这些方面。

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