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首页> 外文期刊>Annual Review of Immunology >Innate Immune Pattern Recognition: A Cell Biological Perspective
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Innate Immune Pattern Recognition: A Cell Biological Perspective

机译：天生免疫模式识别：细胞生物学视角

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摘要

Receptors of the innate immune system detect conserved determinants of microbial and viral origin. Activation of these receptors initiates signaling events that culminate in an effective immune response. Recently, the view that innate immune signaling events rely on and operate within a complex cellular infrastructure has become an important framework for understanding the regulation of innate immunity. Compartmentalization within this infrastructure provides the cell with the ability to assign spatial information to microbial detection and regulate immune responses. Several cell biological processes play a role in the regulation of innate signaling responses; at the same time, innate signaling can engage cellular processes as a form of defense or to promote immunological memory. In this review, we highlight these aspects of cell biology in pattern-recognition receptor signaling by focusing on signals that originate from the cell surface, from endosomal compartments, and from within the cytosol.
机译：先天免疫系统的受体检测微生物和病毒源的保守决定因素。这些受体的激活引发了有效免疫应答的信号传导事件。最近，天体免疫信号传导事件依赖于复杂的蜂窝基础设施内部运作的观点已成为理解先天免疫调节的重要框架。该基础设施内的划分器提供了细胞，其能够将空间信息分配给微生物检测并调节免疫应答。几种细胞生物学过程在规定先天信号响应的调节中起作用;同时，先天信令可以将蜂窝工艺作为防御形式或促进免疫记忆。在本文中，我们通过专注于源自细胞表面的信号，从内体隔室和胞质溶质内突出了模式识别受体信号传导中的这些方面。

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  • 来源
    《Annual Review of Immunology》 |2015年第null期|共34页
  • 作者

    Brubaker Sky W.; Bonham Kevin S.; Zanoni Ivan; Kagan Jonathan C.;

  • 作者单位

    Harvard Univ Sch Med Boston Childrens Hosp Div Gastroenterol Boston MA 02115 USA;

    Harvard Univ Sch Med Boston Childrens Hosp Div Gastroenterol Boston MA 02115 USA;

    Harvard Univ Sch Med Boston Childrens Hosp Div Gastroenterol Boston MA 02115 USA;

    Harvard Univ Sch Med Boston Childrens Hosp Div Gastroenterol Boston MA 02115 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
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