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A pilot study of actigraphy as an objective measure of SSRI activation symptoms; results from a randomized placebo controlled psychopharmacological treatment study

机译：书法作为一项SSRI激活症状的客观指标的初步研究；安慰剂对照的心理药物治疗研究的结果

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Selective serotonin reuptake inhibitors (SSRIs) are an efficacious and effective treatment for pediatric obsessive-compulsive disorder (OCD) but have received scrutiny due to a potential side effect constellation called activation syndrome. While recent research introduced a subjective measure of activation syndrome, objective measures have not been tested. This pilot study, using data from a larger randomized-controlled trial, investigated the potential of actigraphy to provide an objective measure of activation symptoms in 44 youths with OCD beginning an SSRI medication regimen. Data were collected over the first four weeks of a multisite, parallel, double-blind, randomized, placebo controlled psychopharmacological treatment study and statistical modeling was utilized to test how activation syndrome severity predicts daily and nightly activity levels. Results indicated that youths with higher activation symptoms had lower daytime activity levels when treatment averages were analyzed; in contrast youths who experienced onset of activation symptoms one week were more likely to have higher daytime and night-time activity ratings that week. Results support actigraphy as a potential objective measure of activation symptoms. Subsequent studies are needed to confirm these findings and test clinical applications for use by clinicians to monitor activation syndrome during SSRI treatment. National Institutes of Health (5UO1 MH078594-01); .
机译：选择性5-羟色胺再摄取抑制剂（SSRIs）是一种有效且有效的治疗小儿强迫症（OCD）的方法，但由于潜在的副作用，即活化综合征而受到严格审查。尽管最近的研究引入了激活综合征的主观测量方法，但尚未测试客观测量方法。这项前瞻性研究使用了一项较大的随机对照试验中的数据，调查了书法的潜力，以客观地衡量44名开始​​采用SSRI治疗方案的OCD青年的激活症状。在多站点，平行，双盲，随机，安慰剂对照的心理药物治疗研究的前四个星期中收集数据，并利用统计模型测试激活综合征的严重程度如何预测每日和每晚的活动水平。结果表明，分析治疗平均值时，具有较高激活症状的年轻人的白天活动水平较低；相比之下，一周内出现激活症状发作的年轻人在该周白天和夜间的活动评分较高。结果支持书法作为激活症状的潜在客观指标。需要进行后续研究以证实这些发现并测试临床应用，以供临床医生在SSRI治疗期间监测活化综合征。国立卫生研究院（5UO1 MH078594-01）; 。

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