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Enamel Carious Lesion Development in Response to Sucrose and Fluoride Concentrations and to Time of Biofilm Formation: An Artificial-Mouth Study

机译：釉质龋病发展对蔗糖和氟化物浓度和生物膜形成时间的响应：人工口腔研究。

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The aim of this study was to evaluate both sucrose and fluoride concentrations and time of biofilm formation on enamel carious lesions induced by an in vitro artificial-mouth caries model. For Study 1, biofilms formed by streptococci and lactobacilli were grown on the surface of human enamel slabs and exposed to artificial saliva containing 0.50 or 0.75 ppmF (22.5 h/d) and broth containing 3 or 5% sucrose (30 min; 3x/d) over 5 d. In Study 2, biofilms were grown in the presence of 0.75 ppmF and 3% sucrose over 3 and 9 days. Counts of viable cells on biofilms, lesion depth (LD), and the integrated mineral loss (IML) on enamel specimens were assessed at the end of the tested conditions. Counts of total viable cells and L. casei were affected by sucrose and fluoride concentrations as well as by time of biofilm formation. Enamel carious lesions were shallower and IML was lower in the presence of 0.75 ppmF than in the presence of 0.50 ppmF (P < 0.005). No significant effect of sucrose concentrations was found with respect to LD and IML (P > 0.25). Additionally, deeper lesions and higher IML were found after 9 d of biofilm formation (P < 0.005). Distinct sucrose concentrations did not affect enamel carious lesion development. The severity of enamel demineralization was reduced by the presence of the higher fluoride concentration. Additionally, an increase in the time of biofilm formation produced greater demineralization. Our results also suggest that the present model is suitable for studying aspects related to caries lesion development.
机译：这项研究的目的是评估蔗糖和氟化物的浓度以及体外人工口龋模型诱发的釉质龋病变上生物膜形成的时间。对于研究1，由链球菌和乳杆菌形成的生物膜生长在人类牙釉质平板的表面，并暴露于含有0.50或0.75 ppmF（22.5 h / d）的人造唾液和含有3或5％蔗糖的肉汤（30分钟； 3x / d）。 ）超过5天。在研究2中，生物膜在0.75 ppmF和3％蔗糖的存在下生长了3天和9天。在测试条件结束时，评估了生物膜上的活细胞计数，病变深度（LD）和牙釉质标本上的综合矿物质损失（IML）。蔗糖和氟化物的浓度以及生物膜形成的时间会影响总活细胞和干酪乳杆菌的计数。 0.75 ppmF时的牙釉质龋病灶较浅，IML低于0.50 ppmF时的IML（P <0.005）。相对于LD和IML，未发现蔗糖浓度的显着影响（P> 0.25）。此外，在形成生物膜9天后发现了更深的病变和更高的IML（P <0.005）。不同的蔗糖浓度不影响釉质龋病的发展。较高氟化物浓度的存在降低了釉质脱矿质的严重性。另外，生物膜形成时间的增加产生了更大的脱矿质作用。我们的结果还表明，本模型适用于研究与龋损发展有关的方面。

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