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How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans

机译:环境因素如何影响生命周期和发展?早期分化后生动物的实验框架

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摘要

Ecological developmental biology (eco-devo) explores the mechanistic relationships between the processes of individual development and environmental factors. Recent studies imply that some of these relationships have deep evolutionary origins, and may even predate the divergences of the simplest extant animals, including cnidarians and sponges. Development of these early diverging metazoans is often sensitive to environmental factors, and these interactions occur in the context of conserved signaling pathways and mechanisms of tissue homeostasis whose detailed molecular logic remain elusive. Efficient methods for transgenesis in cnidarians together with the ease of experimental manipulation in cnidarians and sponges make them ideal models for understanding causal relationships between environmental factors and developmental mechanisms. Here, we identify major questions at the interface between animal evolution and development and outline a road map for research aimed at identifying the mechanisms that link environmental factors to developmental mechanisms in early diverging metazoans.
机译:生态发展生物学(eco-devo)探讨了个体发展过程与环境因素之间的机械关系。最近的研究表明,这些关系中的某些具有很深的进化起源,甚至可能早于现存最简单的动物(包括虫和海绵)的差异。这些早期发散的后生动物的发育通常对环境因素敏感,并且这些相互作用发生在保守的信号传导途径和组织稳态的机制中,其详细的分子逻辑仍然难以捉摸。 cnidarians中高效的转基因方法,以及cnidarians和海绵中实验操作的简便性,使其成为了解环境因素与发育机制之间因果关系的理想模型。在这里,我们确定了动物进化与发育之间的主要问题,并概述了旨在确定将环境因素与后生后生动物的发育机制联系起来的机制的研究路线图。

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