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首页> 美国卫生研究院文献>other >Modifications in Lipid Levels Are Independent of Serum TNF-α in Rheumatoid Arthritis: Results of an Observational 24-Week Cohort Study Comparing Patients Receiving Etanercept Plus Methotrexate or Methotrexate as Monotherapy
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Modifications in Lipid Levels Are Independent of Serum TNF-α in Rheumatoid Arthritis: Results of an Observational 24-Week Cohort Study Comparing Patients Receiving Etanercept Plus Methotrexate or Methotrexate as Monotherapy

机译：类风湿关节炎中脂质水平的变化与血清TNF-α无关：一项观察性24周队列研究的结果该研究比较接受Etanercept加甲氨蝶呤或甲氨蝶呤作为单一疗法的患者

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Objective. To compare the modifications in lipids between patients with rheumatoid arthritis (RA) receiving etanercept plus methotrexate (ETA + MTX) versus methotrexate (MTX) and their relationship with serum levels of tumor necrosis factor-alpha (TNF-α). Methods. In an observational cohort study, we compared changes in lipid levels in patients receiving ETA + MTX versus MTX in RA. These groups were assessed at baseline and at 4 and 24 weeks, measuring clinical outcomes, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, and TNF-α. Results. Baseline values for lipid levels were similar in both groups. HDL-C levels increased significantly only in the ETA + MTX group (from 45.5 to 50.0 mg/dL at 4 weeks, a 10.2% increase, P < 0.001, and to 56.0 mg/dL at 24 weeks, a 25.1% increase, P < 0.001), while other lipids underwent no significant changes. ETA + MTX also exhibited a significant increase in TNF-α (44.8 pg/mL at baseline versus 281.4 pg/mL at 24 weeks, P < 0.001). The MTX group had no significant changes in lipids or TNF-α. Significant differences in HDL-C between groups were observed at 24 weeks (P = 0.04) and also in TNF-α  (P = 0.01). Conclusion. HDL-C levels increased significantly following treatment with ETA + MTX, without a relationship with decrease of TNF-α.
机译：目的。为了比较接受依那西普联合甲氨蝶呤（ETA + MTX）与甲氨蝶呤（MTX）的类风湿性关节炎（RA）患者之间脂质的变化及其与血清肿瘤坏死因子-α（TNF-α）的关系。方法。在一项观察性队列研究中，我们比较了接受ETA + MTX与MTX的RA患者的血脂水平变化。这些组在基线，第4和24周进行评估，测量临床结局，总胆固醇，甘油三酸酯，高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇和TNF-α。结果。两组的血脂水平基线值相似。 HDL-C水平仅在ETA + MTX组中显着增加（4周时从45.5增至50.0μmg/ dL，增加10.2％，P <0.001,24周时增至56.0μmg/ dL，增加25.1％，P <0.001），而其他脂质无明显变化。 ETA + MTX也表现出TNF-α的显着增加（基线时为44.8μpg/ mL，而24周时为281.4μpg/ mL，P <0.001）。 MTX组的脂质或TNF-α无明显变化。在24周时，两组之间的HDL-C有显着差异（P = 0.04），在TNF-α-中也有显着差异（P = 0.01）。结论。用ETA + MTX治疗后，HDL-C水平显着升高，与TNF-α降低无关。

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