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Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice

机译：主要的组织相容性复合物I类相关分子控制小鼠肝脏中自然杀手1.1+ T细胞受体α/β+细胞的CD4 + 8-和CD4-8-亚群的发育

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Normal mouse liver contains prominent subsets of CD4+8- and CD4-8- T cell receptor (TCR)-alpha/beta+ cells with intermediate TCR levels. We show here that these cells express the natural killer (NK)1.1 surface antigen and have a restricted TCRV beta repertoire that is highly skewed to V beta 7 and V beta 8. Surprisingly, both CD4+8- and CD4-8- subsets of NK1.1+TCR-alpha/beta+ cells are absent in the liver of beta 2-microglobulin deficient mice, which do not express major histocompatibility complex (MHC) class I or "class I-like" molecules. Analysis of reciprocal radiation bone marrow chimeras established with beta 2-microglobulin deficient and wild-type mice demonstrates that MHC class I expression on radiosensitive (presumably hematopoietic) cells is required for the development of NK1.1+TCR-alpha/beta+ cells in the liver. In the liver of MHC class II deficient mice, the CD4+8- and CD4- 8- subsets of NK1.1+TCR-alpha/beta+ cells develop normally. Collectively our data suggest that NK1.1+TCR-alpha/beta+ cells in liver require interaction with a MHC class I-related ligand on hematopoietic cells for their development. This unusual property of liver T cells is shared by a subset of CD4-8-NK1.1+TCR-alpha/beta+ thymocytes, suggesting a common lineage independent of the mainstream of T cell development.

机译：正常小鼠肝脏中含有CD4 + 8-和CD4-8- T细胞受体（TCR）-alpha / beta +细胞的显着亚群，具有中等TCR水平。我们在这里显示这些细胞表达天然杀伤（NK）1.1表面抗原，并具有受限制的TCRV beta组成部分，该部分高度偏向V beta 7和V beta8。令人惊讶的是，CD4 + 8-和CD4-8-的子集β2-微球蛋白缺陷型小鼠的肝脏中不存在NK1.1 + TCR-alpha / beta +细胞，这些小鼠不表达主要的组织相容性复合物（MHC）I类或“ I类”分子。用β2-微球蛋白缺陷型和野生型小鼠建立的相互辐射骨髓嵌合体的分析表明，NK1.1 + TCR-alpha / beta +细胞的发育需要放射敏感性（推测是造血的）细胞上的MHC I类表达。肝。在MHC II类缺陷小鼠的肝脏中，NK1.1 + TCR-alpha / beta +细胞的CD4 + 8-和CD4-8-亚群正常发育。总体而言，我们的数据表明肝脏中的NK1.1 + TCR-alpha / beta +细胞需要与造血细胞上的MHC I类相关配体相互作用才能发育。肝T细胞的这种非同寻常的性质由CD4-8-NK1.1 + TCR-alpha / beta +胸腺细胞的一个子集共享，这暗示了一个独立于T细胞发育主流的共同谱系。

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期刊名称 The Journal of Experimental Medicine
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年(卷),期 1994(180),2
年度 1994
页码 699–704
总页数 6
原文格式 PDF
正文语种
中图分类免疫学;医学史;
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专利

1. Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice. [J] . T Ohteki, H R MacDonald The Journal of Experomental Medicine . 1994,第2期

机译：主要的组织相容性复杂的I类相关分子控制着小鼠肝脏中自然杀手1.1+ T细胞受体α/β+细胞的CD4 + 8-和CD4-8-亚型的发育。
2. Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice. [J] . T Ohteki, H R MacDonald The Journal of Experomental Medicine . 1994,第2期

机译：主要的组织相容性复杂的I类相关分子控制着小鼠肝脏中自然杀手1.1+ T细胞受体α/β+细胞的CD4 + 8-和CD4-8-亚型的发育。
3. An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. [J] . O Lantz, A Bendelac The Journal of Experomental Medicine . 1994,第3期

机译：小鼠和人类的主要组织相容性复合体I类特异性CD4 +和CD4-8- T细胞的唯一子集使用不变的T细胞受体α链。
4. Invariant chain regulates the major histocompatibility complex class II peptide repertoire of cell-based cancer vaccines. [C] . Olesya Y. Chornoguz, Lydia Grmai, Alexei Gapeev, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：不变链调节细胞基癌症疫苗的主要组织相容性复合体II类肽曲目。
5. CELLULAR AND BIOCHEMICAL STUDIES OF CLASS II MOLECULES ENCODED BY THE HLA-D REGION OF THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX. [D] . LINNER, KRISTIN MARIE. 1987

机译：人类主要组织相容性复合体HLA-D区域编码的II类分子的细胞和生物化学研究。
6. An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans [O] . 1994

机译：小鼠和人类的主要组织相容性复合体I类特异性CD4 +和CD4-8- T细胞的唯一子集使用不变的T细胞受体α链
7. Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice [O] . 1994

机译：主要的组织相容性复合物I类相关分子控制小鼠肝脏中自然杀手1.1+ T细胞受体α/β+细胞的CD4 + 8-和CD4-8-亚群的发育
8. Role of the Major Histocompatibility Complex in T Cell Activation of B Cell Subpopulations, Lyb-5(+) and Lyb-5(-) B Cell Subpopulations Differ in Their Requirement for Major Histocompatibility Complex-Restricted T Cell Recognition [R] . Singer, A., Morrissey, P. J., Hathcock, K. S., 1981

机译：主要组织相容性复合物在B细胞亚群，Lyb-5（+）和Lyb-5（ - ）B细胞亚群的T细胞活化中的作用不同于它们对主要组织相容性复杂限制性T细胞识别的要求

Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice

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