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Cytotoxic Effects of the Radiocontrast Agent Iotrolan and Anesthetic Agents Bupivacaine and Lidocaine in Three-Dimensional Cultures of Human Intervertebral Disc Nucleus Pulposus Cells: Identification of the Apoptotic Pathways

机译：放射性对比剂艾托洛兰和麻醉剂布比卡因和利多卡因在人椎间盘髓核细胞三维培养物中的细胞毒作用：凋亡途径的鉴定。

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BackgroundDiscography and discoblock are imaging procedures used to diagnose discogenic low back pain. Although needle puncture of the intervertebral disc (IVD) itself induces disc degeneration, the agents used in these procedures may also have harmful effects on IVD cells. The purpose of this study was to analyze whether radiocontrast agents and local anesthetic agents have detrimental effects on human nucleus pulposus (NP) cells.

机译：背景技术Discography和discoblock是用于诊断椎间盘源性下腰痛的成像程序。尽管椎间盘（IVD）本身的针刺会引起椎间盘退变，但这些程序中使用的药物也可能对IVD细胞产生有害影响。这项研究的目的是分析放射性对比剂和局部麻醉剂是否对人髓核（NP）细胞具有有害作用。

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Koji Iwasaki; Hideki Sudo; Katsuhisa Yamada; Manabu Ito; Norimasa Iwasaki;
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年(卷),期 -1(9),3
年度 -1
页码 e92442
总页数 7
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1. Cytotoxicity of local anesthetics and nonionic contrast agents on bovine intervertebral disc cells cultured in a three-dimensional culture system [J] . CheeA.V., RenJ., LenartB.A., The spine journal: official journal of the North American Spine Society . 2014,第3期

机译：三维麻醉系统中培养的局麻药和非离子型造影剂对牛椎间盘细胞的细胞毒性
2. Metabolic effects of vitamin D active metabolites in monolayer and micromass cultures of nucleus pulposus and annulus fibrosus cells isolated from human intervertebral disc [J] . ColombiniA., LanteriP., LombardiG., The international journal of biochemistry and cell biology . 2012,第6期

机译：维生素D活性代谢产物在分离自人椎间盘的髓核和纤维环细胞的单层和微团培养中的代谢作用
3. Potential of co-culture of nucleus pulposus mesenchymal stem cells and nucleus pulposus cells in hyperosmotic microenvironment for intervertebral disc regeneration [J] . TaoY.-Q., LiangC.-Z., LiH., Cell biology international. . 2013,第8期

机译：高渗微环境中髓核间充质干细胞和髓核细胞共培养对椎间盘再生的潜力
4. Morphologic characteristics of processes of nucleus pulposus cells in adult human intervertebral Disc [C] . Liu Xiaoyun, Wu Xinghuo, Hui Liu, International conference on photonics and imaging in biology and medicine . 2009

机译：成年人椎间盘髓核细胞过程的形态学特征
5. The Effect of Entrapped Laminin-111 in Three-dimensional Polyethylene Glycol Gels on the Behavior of Nucleus Pulposus Cells from the Intervertebral Disc [D] . Phu, Donna. 2010

机译：三维聚乙二醇凝胶中截留的层粘连蛋白111对椎间盘髓核细胞行为的影响
6. Cytotoxicity of Local Anesthetics and Nonionic Contrast Agents on Bovine Intervertebral Disc Cells Cultured in a Three-Dimensional Culture System [O] . Ana Chee, Jing Ren, Brett A. Lenart, -1

机译：在三维培养系统中培养的局部麻醉药和非离子造影剂对牛椎间盘细胞的细胞毒性
7. Cytotoxic effects of the radiocontrast agent iotrolan and anesthetic agents bupivacaine and lidocaine in three-dimensional cultures of human intervertebral disc nucleus pulposus cells: identification of the apoptotic pathways. [O] . Koji Iwasaki, Hideki Sudo, Katsuhisa Yamada, 2014

机译：放射性对比剂iotrolan和麻醉剂布比卡因和利多卡因在人椎间盘髓核细胞的三维培养物中的细胞毒性作用：鉴定凋亡途径。

Cytotoxic Effects of the Radiocontrast Agent Iotrolan and Anesthetic Agents Bupivacaine and Lidocaine in Three-Dimensional Cultures of Human Intervertebral Disc Nucleus Pulposus Cells: Identification of the Apoptotic Pathways

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