• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >A New Sampling Method for Spleen Stiffness Measurement Based on Quantitative Acoustic Radiation Force Impulse Elastography for Noninvasive Assessment of Esophageal Varices in Newly Diagnosed HCV-Related Cirrhosis
【2h】

A New Sampling Method for Spleen Stiffness Measurement Based on Quantitative Acoustic Radiation Force Impulse Elastography for Noninvasive Assessment of Esophageal Varices in Newly Diagnosed HCV-Related Cirrhosis

机译：基于定量声辐射力脉冲弹性成像技术的脾硬度测量取样新方法用于新诊断的HCV相关性肝硬化食管静脉曲张的无创评估

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In our study, we evaluated the feasibility of a new sampling method for splenic stiffness (SS) measurement by Quantitative Acoustic Radiation Force Impulse Elastography (Virtual Touch Tissue Quantification (VTTQ)).We measured SS in 54 patients with HCV-related cirrhosis of whom 28 with esophageal varices (EV), 27 with Chronic Hepatitis C (CHC) F1–F3, and 63 healthy controls. VTTQ-SS was significantly higher among cirrhotic patients with EV (3.37 m/s) in comparison with controls (2.19 m/s, P < 0.001), CHC patients (2.37 m/s, P < 0.001), and cirrhotic patients without EV (2.7 m/s, P < 0.001). Moreover, VTTQ-SS was significantly higher among cirrhotic patients without EV in comparison with both controls (P < 0.001) and CHC patients (P < 0.01). The optimal VTTQ-SS cut-off value for predicting EV was 3.1 m/s (AUROC = 0.96, sensitivity 96.4%, specificity 88.5%, positive predictive value 90%, negative predictive value 96%, positive likelihood ratio 8.36, and negative likelihood ratio 0.04). In conclusion, VTTQ-SS is a promising noninvasive and reliable diagnostic tool to screen cirrhotic patients for EV and reduce the need for upper gastrointestinal endoscopy. By using our cut-off value of 3.1 m/s, we would avoid endoscopy in around 45% of cirrhotic subjects, with significant time and cost savings.
机译：在我们的研究中，我们评估了通过定量声辐射力脉冲弹性成像（虚拟触摸组织定量（VTTQ））测量脾硬度（SS）的新采样方法的可行性。我们在54例HCV相关性肝硬化患者中测量了SS食管静脉曲张（EV）28例，慢性丙型肝炎（CHC）F1-F3 27例，健康对照63例。与对照组（2.19 m / s，P <0.001），CHC患者（2.37 m / s，P <0.001）和无EV的肝硬化患者相比，EV的肝硬化患者（3.37（m / s）的VTTQ-SS显着更高（2.7 m / s，P <0.001）。此外，与对照组（P <0.001）和CHC患者（P <0.01）相比，没有EV的肝硬化患者的VTTQ-SS显着更高。预测EV的最佳VTTQ-SS截止值是3.1μm/ s（AUROC = 0.96，灵敏度96.4％，特异性88.5％，阳性预测值90％，阴性预测值96％，阳性可能性比8.36，阴性可能性比0.04）。总之，VTTQ-SS是一种有前途的无创且可靠的诊断工具，可以筛查肝硬化患者的EV并减少上消化道内窥镜检查的需要。通过使用我们的3.1μm/ s的临界值，我们将避免在大约45％的肝硬化患者中进行内窥镜检查，从而节省大量时间和成本。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号