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首页> 美国卫生研究院文献>other >Prolonged Hypocalcemic Effect by Pulmonary Delivery of Calcitonin Loaded Poly(Methyl Vinyl Ether Maleic Acid) Bioadhesive Nanoparticles
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Prolonged Hypocalcemic Effect by Pulmonary Delivery of Calcitonin Loaded Poly(Methyl Vinyl Ether Maleic Acid) Bioadhesive Nanoparticles

机译：肺降钙素负载的聚（甲基乙烯基醚马来酸）生物粘附性纳米颗粒的肺递送可延长降血钙作用。

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The purpose of the present study was to design a pulmonary controlled release system of salmon calcitonin (sCT). Therefore, poly(methyl vinyl ether maleic acid) [P(MVEMA)] nanoparticles were prepared by ionic cross-linking method using Fe2+ and Zn2+ ions. Physicochemical properties of nanoparticles were studied in vitro. The stability of sCT in the optimized nanoparticles was studied by electrophoretic gel method. Plasma calcium levels until 48 h were determined in rats as pulmonary-free sCT solution or nanoparticles (25 μg·kg−1), iv solution of sCT (5 μg·kg−1), and pulmonary blank nanoparticles. The drug remained stable during fabrication and tests on nanoparticles. The optimized nanoparticles showed proper physicochemical properties. Normalized reduction of plasma calcium levels was at least 2.76 times higher in pulmonary sCT nanoparticles compared to free solution. The duration of hypocalcemic effect of pulmonary sCT nanoparticles was 24 h, while it was just 1 h for the iv solution. There was not any significant difference between normalized blood calcium levels reduction in pulmonary drug solution and iv injection. Pharmacological activity of nanoparticles after pulmonary delivery was 65% of the iv route. Pulmonary delivery of P(MVEMA) nanoparticles of sCT enhanced and prolonged the hypocalcemic effect of the drug significantly.
机译：本研究的目的是设计鲑鱼降钙素（sCT）的肺控释系统。因此，采用Fe 2 + 和Zn 2 + 离子通过离子交联法制备了聚甲基乙烯基醚马来酸[P（MVEMA）]纳米颗粒。体外研究了纳米粒子的理化性质。通过电泳凝胶法研究了sCT在优化纳米颗粒中的稳定性。确定大鼠血浆钙水平直至48 h为无肺sCT溶液或纳米颗粒（25μg·kg -1 ），静脉输注sCT溶液（5μg·kg -1） sup>）和肺空白纳米颗粒。该药物在制造和纳米颗粒测试过程中保持稳定。优化的纳米颗粒表现出适当的理化性质。与游离溶液相比，肺部sCT纳米颗粒中血浆钙水平的标准化降低至少高出2.76倍。肺部sCT纳米颗粒的降血钙作用持续时间为24 h，而静脉输液仅为1 justh。肺部药物溶液中的正常血钙水平降低与静脉注射之间没有显着差异。肺部递送后纳米颗粒的药理活性为静脉内途径的65％。肺部递送sCT的P（MVEMA）纳米颗粒可显着增强并延长药物的降血钙作用。

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